This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Targeting hypoxia in solid and haematological malignancies
Journal of Experimental & Clinical Cancer Research Open Access 02 November 2022
-
JunB is a key regulator of multiple myeloma bone marrow angiogenesis
Leukemia Open Access 18 May 2021
-
Crosstalk between endoplasmic reticulum stress and oxidative stress: a dynamic duo in multiple myeloma
Cellular and Molecular Life Sciences Open Access 18 February 2021
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Podar K, Richardson PG, Hideshima T, Chauhan D, Anderson KC . The malignant clone and the bone-marrow environment. Best Pract Res Clin Haematol 2007; 20: 597–612.
Vacca A, Ribatti D, Presta M, Minischetti M, Iurlaro M, Ria R et al. Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma. Blood 1999; 93: 3064–3073.
Brahimi-Horn MC, Chiche J, Pouysségur J . Hypoxia and cancer. J Mol Med 2007; 85: 1301–1307.
Weidemann A, Johnson RS . Biology of HIF-1α. Cell Death Differ 2008; 15: 621–627.
Harrison JS, Rameshwar P, Chang V, Bandari P . Oxygen saturation in the bone marrow of healthy volunteers. Blood 2002; 99: 394.
Kumar S, Witzig TE, Timm M, Haug J, Wellik L, Kimlinger TK et al. Bone marrow angiogenic ability and expression of angiogenic cytokines in myeloma: evidence favoring loss of marrow angiogenesis inhibitory activity with disease progression. Blood 2004; 104: 1159–1165.
Hose D, Moreaux J, Meissner T, Seckinger A, Goldschmidt H, Benner A et al. Induction of angiogenesis by normal and malignant plasma cells. Blood 2009; 114: 123–148.
Asosingh K, De Raeve H, de Ridder M, Storme GA, Willems A, Van Riet I et al. Role of the hypoxic bone marrow microenvironment in 5T2MM murine myeloma tumor progression. Haematologica 2005; 90: 810–817.
Ceradini DJ, Kulkarni AR, Callaghan MJ, Tepper OM, Bastidas N, Kleinman ME et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 2004; 10: 858–864.
Stewart M, Talks K, Leek R, Turley H, Pezzella F, Harris A et al. Expression of angiogenic factors and hypoxia inducible factors HIF 1, HIF 2 and CA IX in non-Hodgkin's lymphoma. Histopathology 2002; 40: 253–260.
Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 1999; 59: 5830–5835.
Shin DH, Chun YS, Lee DS, Huang LE, Park JW . Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1. Blood 2008; 111: 3131–3136.
Lu L, Payvandi F, Wu L, Zhang LH, Hariri RJ, Man HW et al. The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions. Microvasc Res 2009; 77: 78–86.
Acknowledgements
We thank the ‘Associazione Italiana Contro le Leucemie’ (AIL) Parma section and the Associazione Italiana Ricerca sul Cancro (AIRC) for the financial support (IG2009). This study was supported by grants from the ‘International Myeloma Foundation’; the ‘Italian Minister of Health-Progetti Regione Emilia Romagna’.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Additional information
Supplementary Information accompanies the paper on the Leukemia website
Rights and permissions
About this article
Cite this article
Colla, S., Storti, P., Donofrio, G. et al. Low bone marrow oxygen tension and hypoxia-inducible factor-1α overexpression characterize patients with multiple myeloma: role on the transcriptional and proangiogenic profiles of CD138+ cells. Leukemia 24, 1967–1970 (2010). https://doi.org/10.1038/leu.2010.193
Published:
Issue Date:
DOI: https://doi.org/10.1038/leu.2010.193
This article is cited by
-
Targeting hypoxia in solid and haematological malignancies
Journal of Experimental & Clinical Cancer Research (2022)
-
JunB is a key regulator of multiple myeloma bone marrow angiogenesis
Leukemia (2021)
-
Crosstalk between endoplasmic reticulum stress and oxidative stress: a dynamic duo in multiple myeloma
Cellular and Molecular Life Sciences (2021)
-
Influence of metformin on HIF-1 pathway in multiple myeloma
Pharmacological Reports (2020)
-
TRIM44 promotes quiescent multiple myeloma cell occupancy and survival in the osteoblastic niche via HIF-1α stabilization
Leukemia (2019)