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Innate immunity as orchestrator of stem cell mobilization

Leukemia volume 24, pages 1667–1675 (2010)Cite this article

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Abstract

Hematopoietic stem and progenitor cells (HSPCs), as well as other types of stem cells, circulate under steady-state conditions at detectable levels in peripheral blood (PB), with their numbers increasing in response to stress, inflammation and tissue/organ injury. This mobilization process may be envisioned as a danger-sensing response mechanism triggered by hypoxia or mechanical or infection-induced tissue damage that recruits into PB different types of stem cells that have a role in immune surveillance and organ/tissue regeneration. Mobilization is also significantly enhanced by the administration of pharmacological agents, which has been exploited in hematological transplantology as a means to obtain HSPCs for hematopoietic reconstitution. In this review we will present mounting evidence that innate immunity orchestrates this evolutionarily conserved mechanism of HSPC mobilization.

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Acknowledgements

Supported by NIH grant R01 CA105847, NIH R01 DK070577 and European Union structural funds, Innovative Economy Operational Program POIG.01.01.01-00-109/09-01 and Stella and Henry Endowment to MZR.

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Authors and Affiliations

  1. Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA

    M Z Ratajczak, C H Kim, M Kucia & J Ratajczak

  2. Department of Physiology Pomeranian Medical University, Szczecin, Poland

    M Z Ratajczak, M Kucia & J Ratajczak

  3. Third Division of Cardiology, Medical University of Silesia, Katowice, Poland

    W Wojakowski

  4. Department of Medicine, University of Alberta, Edmonton, AB, Canada

    A Janowska-Wieczorek

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  2. C H Kim
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  3. W Wojakowski
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  4. A Janowska-Wieczorek
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  5. M Kucia
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  6. J Ratajczak
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Correspondence to M Z Ratajczak.

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Ratajczak, M., Kim, C., Wojakowski, W. et al. Innate immunity as orchestrator of stem cell mobilization. Leukemia 24, 1667–1675 (2010). https://doi.org/10.1038/leu.2010.162

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  • DOI: https://doi.org/10.1038/leu.2010.162

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