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The role of vertebral augmentation in multiple myeloma: International Myeloma Working Group Consensus Statement

Leukemia volume 22, pages 1479–1484 (2008)Cite this article

A Corrigendum to this article was published on 13 August 2008

There are approximately 20 000 new patients diagnosed with myeloma in the United States each year.1 With the availability of better treatments and resultant improved survival, there are currently close to 100 000 patients living with myeloma in the United States. Similar incidence and prevalence rates exist throughout Europe.2 Of these patients, the spine is affected by osteolytic and/or osteopenic bone disease in 70%.3 Myeloma is the commonest primary cancer affecting the spine. Painful vertebral compression fractures (VCFs) affect approximately 30% of myeloma patients. As myeloma patients live longer, it is especially relevant to provide the best available treatment for pain and reduce disabilities that can result from VCFs.4

The focus of this summary is to assess the role of minimally invasive percutaneous injection of polymethyl methacrylate (PMMA), first developed as ‘vertebroplasty’ in France in the late 1980s. Considerable experience accrued, especially in Europe, with the use of vertebroplasty as treatment for painful VCFs. The fractured bone fragments are stabilized and strengthened by PMMA and pain is substantially improved. A more recent modification of vertebroplasty is percutaneous balloon kyphoplasty whereby inflation of a balloon prior to PMMA injection can restore vertebral height and reduce kyphotic deformity in addition to stabilizing the fractured vertebral body.

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Author information

Author notes

  1. M A Hussein, F D Vrionis, R Allison, J Berenson, S Berven, E Erdem, S Giralt, S Jagannath, R A Kyle, S LeGrand, R Pflugmacher, N Raje, S V Rajkumar, L Randall, D Roodman, D Siegel, R Vescio, J Zonder and B G M Durie: See Appendix for members of the International Myeloma Working Group

Authors and Affiliations

  1. Department of Hematologic Malignancies, H Lee Moffitt Cancer Center, Tampa, FL, USA

    M A Hussein

  2. Department of Neuro-Oncology, H Lee Moffitt Cancer Center, Tampa, FL, USA

    F D Vrionis

  3. Department of Radiation Oncology, Brody School of Medicine at ECU, Greenville, NC, USA

    R Allison

  4. Department of Hematology/Medical Oncology, Institute for Myeloma & Bone Cancer Research, Los Angeles, CA, USA

    J Berenson

  5. Department of Orthopaedic Surgery, University of California, San Francisco, CA, USA

    S Berven

  6. Division of Radiology, Section of Interventional Neuroradiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA

    E Erdem

  7. Stem Cell Transplantation & Cellular Therapy Department, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    S Giralt

  8. Department of Medical Oncology/Internal Medicine, St Vincent's Comprehensive Cancer Center, New York, NY, USA

    S Jagannath

  9. Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, USA

    R A Kyle & S V Rajkumar

  10. Department of Medical Oncology/Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA

    S LeGrand

  11. Department of Musculature, Charité der Humboldt Universitàt, Berlin, Germany

    R Pflugmacher

  12. Department of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    N Raje

  13. Department of Orthopaedics, Huntsman Cancer Institute, Salt Lake City, UT, USA

    L Randall

  14. Department of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    D Roodman

  15. Department of Medical Oncology, Hackensack Cancer Center, Hackensack, NJ, USA

    D Siegel

  16. Department of Hematology/Oncology, Cedars-Sinai Outpatient Cancer Center, Los Angeles, CA, USA

    R Vescio & B G M Durie

  17. Department of Medicine, Division of Hematology-Oncology, Karmanos Cancer Center, Wayne State University School of Medicine, Detroit, MI, USA

    J Zonder

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  1. M A Hussein
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Consortia

on behalf of the International Myeloma Working Group

Corresponding authors

Correspondence to M A Hussein or B G M Durie.

Appendix

Appendix

International Myeloma Working Group:

Ray Alexanian, MD Anderson, Houston, Texas, USA

Kenneth Anderson, DFCI, Boston, Massachusetts, USA

Michael Attal, Purpan Hospital, Toulouse, France

Herve Avet-Loiseau, Institute de Biologie, Nantes, France

Ashraf Badros, University of Maryland, Baltimore, Maryland, USA

Leif Bergsagel, Mayo Clinic Scottsdale, Scottsdale, Arizona, USA

Joan Bladé, Hospital Clinica, Barcelona, Spain

Bart Barlogie, MIRT UAMS Little Rock, Arkanas, USA

Regis Batille, Institute de Biologie, Nantes, France

Meral Beksac, Ankara University, Ankara, Turkey

Andrew Belch, Cross Cancer Institute, Alberta, Canada

Bill Bensinger, Fred Hutchinson Cancer Center, Seattle, Washington, USA

Mario Boccadoro, University of Torino, Torino, Italy

Michele Cavo, Universita di Bologna, Bologna, Italy

Wen Ming Chen, MM Research Center of Beijing, Beijing, China

Tony Child, Leeds General Hospital, Leeds, United Kingdom

James Chim, Department of Medicine, Queen Mary Hospital, Hong Kong

Ray Comenzo, Memorial Sloane-Kettering, New York City, New York, USA

John Crowley, Cancer Research and Biostatistics, Seattle, Washington, USA

William Dalton, H Lee Moffitt, Tampa, Florida, USA

Faith Davies, Royal Marsden Hospital, London, England

Cármino de Souza, Univeridade de Campinas, Caminas, Brazil

Michel Delforge, University Hospital Gasthuisberg, Leuven, Belgium

Meletios Dimipoulous, Alexandra Hospital, Athens, Greece

Angela Dispenzieri, Mayo Clinic, Rochester, Minnesota, USA

Hermann Einsele, Universitätsklinik Würzburg, Würzburg, Germany

Theirry Facon, Centre Hospitalier Regional Universitaire de Lille, Lille, France

Dorotea Fantl, Socieded Argentinade Hematolgia, Buenos Aires, Argentina

Jean-Paul Fermand, Hopitaux de Paris, Paris, France

Rafael Fonseca, Mayo Clinic Scottsdale, Scottsdale, Arizona, USA

Gosta Gahrton, Karolinska Institute for Medicine, Huddinge, Sweden

Morie Gertz, Mayo Clinic, Rochester, Minnesota, USA

John Gibson, Royal Prince Alfred Hospital, Sydney, Australia

Hartmut Goldschmidt, University Hospital Heidelberg, Heidelberg, Germany

Philip Greipp, Mayo Clinic, Rochester, Minnesota, USA

Roman Hajek, Brno University, Brno, Czech Republic

Izhar Hardan, Tel Aviv University, Tel Aviv, Israel

Jean-Luc Harousseau, Institute de Biologie, Nantes, France

Hiroyuki Hata, Kumamoto University Hospital, Kumamoto, Japan

Yutaka Hattori, Keio University School of Medicine, Tokyo, Japan

Joy Ho, Royal Prince Alfred Hospital, Sydney, Australia

Vania Hungria, Clinica San Germano, Sao Paolo, Brazil

Mohamad Hussein, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, USA

Shinsuke Ida, Nagoya City University Medical School, Nagoya, Japan

Peter Jacobs, Constantiaberg Medi-Clinic, Plumstead, South Africa

Sundar Jagannath, St Vincent's Comprehensive Cancer Center, New York, New York, USA

Hou Jian, Shanghai Chang Zheng Hospital, Shanghai, China

Douglas Joshua, Royal Prince Alfred Hospital, Sydney, Australia

Michio Kawano, Yamaguchi University, Ube, Japan

Shaji Kumar, Department of Hematology, Mayo Clinic, Minnesota, USA

Robert Kyle, Department of Laboratory Med. and Pathology, Mayo Clinic, Minnesota, USA

Juan Lahuerta, Grupo Espanol di Mieloma, Hospital Universitario, Madrid, Spain

Jae Hoon Lee, Gachon University Gil Hospital, Incheon, Korea

Henk Lokhorst, University Medical CenterUtrecht, Utrecht, The Netherlands

Heinz Ludwig, Wilhelminenspital Der Stat Wien, Vienna, Austria

Xavier LeLeu, Hospital Huriez, CHRU Lille, France

Angelo Maiolino, Rua fonte da Saudade, Rio de Janeiro, Brazil

Jayesh Mehta, Northwestern University, Chicago, Illinois, USA

GianPaolo Merlini, University of Pavia, Pavia, Italy

Philippe Moreau, University Hospital, Nantes, France

Gareth Morgan, Royal Marsden Hospital, London, England

Nikhil Munshi, Diane Farber Cancer Institute, Boston, Massachusetts, USA

Antonio Palumbo, Cathedra Ematologia, Torino, Italy

Santiago Pavlovsky, Fundaleu, Buenos Aires, Argentina

Ruben Niesvizky, Weill Medical College of Cornell University, New York, New York, USA

Yana Novis, Hospital SírioLibanês, Bela Vista, Brazil

Amara Nouel, Hospital Rutz y Paez, Bolivar, Venezuela

Raymond Powles, Leukaemia & Myeloma, Wimbledon, England

Linda Pilarski, University of Alberta, Alberta, Canada

S Vincent Rajkumar, Mayo Clinic, Rochester, Minnesota, USA

Donna Reece, Princess Margaret, Toronto, Canada

Tony Reiman, Cross Cancer Institute, Alberta, Canada

Paul Richardson, Dana Farber Cancer Institute, Boston, Massachusetts, USA

Angelina Rodriquez Morales, Bonco Metro Politano de Sangre, Caracas, Venezuela

Orhan Sezer, Department of Hem/Onc, Universitatsklinikum Charite, Berlin, Germany

John Shaughnessy, M.I.R.T. UAMS, Little Rock, Arkansas, USA

Kazayuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan

David Siegel, Hackensack, Cancer Center, Hackensack, New Jersey, USA

Guido Tricot, M.I.R.T. UAMS, Little Rock, Arkansas, USA

Jesus San Miguel, University of Salamanca, Salamanca, Spain

Seema Singhal, Northwestern University, Chicago, Illinois, USA

Pieter Sonneveld, Erasmus MC, Rotterdam, The Netherlands

Chaim Shustik, McGill, Toronto, Canada

Andrew Spencer, The Alfred Hospital, Melbourne, Australia

Keith Stewart, Mayo Clinic Scottsdale, Scottsdale, Arizona, USA

Patrizia Tosi, Italian Cooperative Group, Istituto di Ematologia Seragnoli, Bologna, Italy

Ingemar Turesson, Department of Hematology, Malmo University, Malmo, Sweden

Brian Van Ness, University of Minnesota, Minneapolis, Minnesota, USA

Ivan Van Riet, Brussels Vrija University, Brussels, Belgium

Robert Vescio, Cedars-Sinai Outpatient Cancer Center, Los Angeles, California, USA

David Vesole, St Vincent's Comprehensive Cancer Center, New York, New York, USA

Anders Waage, University Hospital, Trondheim, Norway NSMG

Michael Wang, M.D. Anderson, Houston, Texas, USA

Donna Weber, MD Anderson, Houston, Texas, USA

Jan Westin, University of Lund, Lund, Sweden

Keith Wheatley, University of Birmingham, Birmingham, United Kingdom

Dina B Yehuda, Department of Hematology, Hadassah University Hospital, Hadassah, Israel

Jeffrey Zonder, SWOG, Department of Hem/Onc., Karmanos Cancer Institute, Michigan, USA

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Hussein, M., Vrionis, F., Allison, R. et al. The role of vertebral augmentation in multiple myeloma: International Myeloma Working Group Consensus Statement. Leukemia 22, 1479–1484 (2008). https://doi.org/10.1038/leu.2008.127

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