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Response to Protocol Review Scenario: Monitor matters

Lab Animal volume 35, pages 16–17 (2006)Cite this article

Several questions should be considered. First, during anesthesia, what parameters will be monitored? We recommend that at a minimum, respiratory rate, heart rate, temperature, corneal/pedal reflexes, blood pressure, and ECG be monitored.

Second, are the methods to provide relief of pain and distress adequate? In this case, perhaps not; aspirin/NSAIDS are minimally effective against surgical pain, and aspirin may be unpalatable in rabbits. Ideally, preemptive opioids with an NSAID (e.g., buprenorphine combined with carprofen, meloxicam, or ketoprofen) should be administered as recommended by the American College of Laboratory Animal Medicine (ACLAM)1.

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References

  1. American College of Laboratory Animal Medicine. Guidelines for the Assessment and Management of Pain in Rodents and Rabbits. http://www.aclam.org/PDF/pub_pain_rod_rab-2006-07.pdf.

  2. American Psychological Association. Guidelines for Ethical Conduct in the Care and Use of Animals. http://www.apa.org/science/anguide.html.

  3. Reznik, G.K. & Padberg, G. Diethylnitrosamine-induced metastasizing hepatocellular carcinomas in New Zealand white rabbits. A tumor model for clinical investigations. J. Cancer. Res. Clin. Oncol. 117(2), 123–129 (1991).

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Authors and Affiliations

  1. Craig is Associate Professor and Chief IACUC Veterinarian, Lockworth is Postdoctoral Fellow, and Naff is Assistant Professor, M.D. Anderson Cancer Center, Houston, TX.,

    Suzanne Craig,  Cynthia Lockworth &  Katherine Naff

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  1. Suzanne Craig
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  2. Cynthia Lockworth
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  3. Katherine Naff
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Craig, S., Lockworth, C. & Naff, K. Response to Protocol Review Scenario: Monitor matters. Lab Anim 35, 16–17 (2006). https://doi.org/10.1038/laban1006-16b

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