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Comparison of ketamine-pentobarbital anesthesia and fentanyl-pentobarbital anesthesia for open-heart surgery in minipigs

Lab Animal volume 38, pages 234–240 (2009)Cite this article

Abstract

The authors analyzed and compared the cardiovascular effects of two anesthetic combinations in minipigs undergoing open-heart surgery and cardiopulmonary bypass. Pigs in group K (n = 15) were anesthetized with low-dose ketamine combined with pentobarbital (5 mg per kg and 20 mg per kg, respectively, for induction; continuous intravenous infusion of 5 mg per kg per h and 10 mg per kg per h, respectively, for maintenance). Pigs in group F (n = 15) were treated with fentanyl and pentobarbital (20 μg per kg and 20 mg per kg, respectively, for induction; continuous intravenous infusion of 20 μg per kg per h and 10 mg per kg per h, respectively, for maintenance). Most pigs remained stable during the surgical procedures and survived for at least one day after surgery; two pigs in group F died during or soon after surgery. Heart rate and mean arterial pressure after bypass were significantly lower in group F than in group K, and pigs in group F required higher doses of inotropic agents to maintain cardiac function. Results suggest that for open-heart surgery and bypass in minipigs, ketamine-pentobarbital anesthesia is associated with more stable cardiovascular conditions than is fentanyl-pentobarbital anesthesia.

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Figure 1: Intravenous route of drug administration after the surgical procedure.
Figure 2: Cardiovascular characteristics.

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Acknowledgements

This study was supported by grant number 30772152 from the National Natural Science Foundation of China.

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Authors and Affiliations

  1. The Heart Center, First Hospital of Tsinghua University, Beijing, China

    Debin Liu,  Mingkui Zhang &  Qingyu Wu

  2. Department of Anaesthesia, First Hospital of Tsinghua University, Beijing, China

    Yanbin Shao &  Xiushu Luan

  3. Clinical Experimental Center, First Hospital of Tsinghua University, Beijing, China

    Chaoxiang Shui

Authors
  1. Debin Liu
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  2. Yanbin Shao
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Correspondence to Debin Liu.

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Liu, D., Shao, Y., Luan, X. et al. Comparison of ketamine-pentobarbital anesthesia and fentanyl-pentobarbital anesthesia for open-heart surgery in minipigs. Lab Anim 38, 234–240 (2009). https://doi.org/10.1038/laban0709-234

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