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Cell Culture Models and Animal Models of Viral Hepatitis. Part II: Hepatitis C

Lab Animal volume 34, pages 39–47 (2005)Cite this article

Abstract

The lack of a preventive vaccine, coupled with common unresponsiveness to treatment and coinfection with HIV, has made HCV a major threat to public health. The authors review in vitro and in vivo models that are being used to study HCV and to develop new treatments and preventive measures.

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Figure 1: Generation of a human hepatoma cell clone containing HCV replicons: cDNA copy of the HCV RNA genome is cloned into a plasmid and the structural genes are replaced by a neomycin phosphotransferase coding region (Neor), the transcription of which is driven by the endogenous internal ribosomal entry site (IRES) of HCV.

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Acknowledgements

The work was supported in part by a grant from the American Cancer Society: RPG-00-066-01-CCE (to C.G.) and the following grants from the National Institutes of Health: RO1-DK 46057 (to J.R.C.), RO1-DK 39137 (to N.R.C.), and the Liver Research Core Center grant DK-P30-41296.

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  1. Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, 10461, NY

    Chandan Guha MD, PhD, Sung-W Lee MD, Namita Roy Chowdhury PhD & Jayanta Roy Chowdhury MD

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Correspondence to Jayanta Roy Chowdhury MD.

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Guha, C., Lee, SW., Chowdhury, N. et al. Cell Culture Models and Animal Models of Viral Hepatitis. Part II: Hepatitis C. Lab Anim 34, 39–47 (2005). https://doi.org/10.1038/laban0205-39

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