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How does high-flow nasal cannulae compare to nasal CPAP for treatment of early respiratory distress?

Manuscript Citation: Roberts CT, et al. "Nasal High-Flow Therapy for Primary Respiratory Support in Preterm Infants". N Engl J Med 2016; 375: 1142–1151. PMID: 27653564.

Journal of Perinatology volume 38, pages 23–25 (2018)Cite this article

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  • Are (population) preterm infants (≥28 to <37 weeks), who are treated with (intervention) heated, humidified, high-flow nasal cannulae (HHHFNC) at (Outcomes) increased risk of treatment failure of early respiratory distress compared to treatment with (comparison) nasal CPAP (NCPAP) (time) over 72 h?

  • In (population) preterm infants (≥28 to <37 weeks), what is the effect of (intervention) high-flow nasal cannulae on (outcome) treatment of early respiratory distress compared with (comparison) nasal CPAP within (time) 72 h?

Are (population) preterm infants (≥28 to <37 weeks), who are treated with (intervention) heated, humidified, high-flow nasal cannulae (HHHFNC) at (Outcomes) increased risk of treatment failure of early respiratory distress compared to treatment with (comparison) nasal CPAP (NCPAP) (time) over 72 h?

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References

  1. Reuter S, Moser C, Baack M . Respiratory distress in the newborn. Pediatr Rev 2014; 35 (10): 417–429.

    Article  Google Scholar 

  2. Hough JL, Shearman AD, Jardine LA, Davies MW . Humidified high flow nasal cannulae: current practice in Australasian nurseries, a survey. J Paediatr Child Health 2012; 48 (2): 106–113.

    Article  Google Scholar 

  3. Ciuffini F, Pietrasanta C, Lavizzari A, Musumeci S, Gualdi C, Sortino S et al. Comparison between two different modes of non-invasive ventilatory support in preterm newborn infants with respiratory distress syndrome mild to moderate: preliminary data. Pediatr Med Chir 2014; 36 (88): 153–158.

    Google Scholar 

  4. Lavizzari A, Colnaghi M, Ciuffini F, Veneroni C, Musumeci S, Cortinovis I et al. Heated, humidified high-flow nasal cannula vs nasal continuous positive airway pressure for respiratory distress syndrome of prematurity: a randomized clinical noninferiority trial. JAMA Pediatr 2016 (e-pub ahead of print; doi:10.1001/jamapediatrics.2016.1243).

  5. Manley BJ, Owen LS, Doyle LW, Andersen CC, Cartwright DW, Pritchard MA et al. High-flow nasal cannulae in very preterm infants after extubation. N Engl J Med 2013; 369 (15): 1425–1433.

    Article  CAS  Google Scholar 

  6. Wilkinson D, Andersen C, O'Donnell CP, De Paoli AG, Manley BJ . High flow nasal cannula for respiratory support in preterm infants. Cochrane Database Syst Rev 2016; 2: CD006405.

    PubMed  Google Scholar 

  7. Roberts CT, Owen LS, Manley BJ, Froisland DH, Donath SM, Dalziel KM et al. Nasal high-flow therapy for primary respiratory support in preterm infants. N Engl J Med 2016; 375 (12): 1142–1151.

    Article  Google Scholar 

  8. Ho JJ, Subramaniam P, Davis PG . Continuous distending pressure for respiratory distress in preterm infants. Cochrane Database Syst Rev 2015; (Issue 7): Art. No.: CD002271.

  9. Morley CJ, Davis PG, Doyle LW, Brion LP, Hascoet J-M, Carlin JB . Nasal CPAP or intubation at birth for very preterm infants. N Engl J Med 2008; 358 (7): 700–708.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Shweta Parmekar wrote the first draft of the manuscript. No honorarium, grant or other form of payment was given to anyone to produce the manuscript.

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Authors and Affiliations

  1. Texas Children’s Newborn Center, Texas Children’s Hospital, Houston, TX, USA

    S Parmekar & J Hagan

  2. Department of Pediatrics, Section of Neonatology, Baylor College of Medicine, Houston, TX, USA

    S Parmekar

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  1. S Parmekar
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  2. J Hagan
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Correspondence to S Parmekar.

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Parmekar, S., Hagan, J. How does high-flow nasal cannulae compare to nasal CPAP for treatment of early respiratory distress?. J Perinatol 38, 23–25 (2018). https://doi.org/10.1038/jp.2017.163

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