Abstract
Objective:
The objective of this study is to determine child health, development and educational outcomes for infants born following preterm prelabor rupture of the membrane (PPROM).
Study Design:
Population-based record linkage cohort study using data from NSW, Australia, 2001 to 2014.
Results:
Of 121 822 births at 20 to 37 weeks, 18 799 (15%) followed PPROM, 56 406 (46%) followed spontaneous labor and 46 617 (38%) were planned. Compared with infants of a similar gestational age born following spontaneous labor or planned delivery, exposure to PPROM did not increase the risk of childhood mortality, childhood hospitalization, developmentally vulnerable at school entry, low reading or numeracy scores. Median latency ranged from 12 days (interquartile range 3 to 37 days) at 25 weeks to 1 day (0 to 2 days) at 36 weeks. Longer latency and more advanced gestational age at birth were associated with better outcomes.
Conclusion:
Infants born following PPROM are at no greater risk of adverse child health, development and education outcomes than those of similar gestational age born without PPROM.
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Acknowledgements
This study uses unit record data from the Australian Early Development Census (AEDC) and the National Assessment Program—Literacy and Numeracy. We thank the Ministry of Health, the NSW Department of Education and Communities (NAPLAN), and the Australian Government Department of Education and Training (AEDC) for provision of population data, and the NSW Centre for Health Record Linkage for record linkage. The findings and views reported in this article are those of the authors and should not be attributed to the departments that provided data. We thank Dr Jillian Patterson for providing supplementary statistical analysis. This work was supported by an Australian National Health and Medical Research Council (NHRMC) project grant (APP1085775). CLR is funded by an NHMRC Senior Research Fellowship (APP1021025). PW and ST were funded through a New South Wales Ministry of Health ‘Population Health and Health Services Research Support Program’ grant.
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Roberts, C., Wagland, P., Torvaldsen, S. et al. Childhood outcomes following preterm prelabor rupture of the membranes (PPROM): a population-based record linkage cohort study. J Perinatol 37, 1230–1235 (2017). https://doi.org/10.1038/jp.2017.123
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DOI: https://doi.org/10.1038/jp.2017.123
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