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Feasibility and safety of enoxaparin whole milligram dosing in premature and term neonates

Journal of Perinatology volume 35, pages 852–854 (2015)Cite this article

Subjects

Abstract

Objective:

The objective of our study was to determine the feasibility and safety of enoxaparin whole milligram dosing in premature and term neonates, and to assess response to treatment.

Study Design:

Retrospective study of neonates with thrombosis treated between January 2008 and December 2014.

Result:

Nineteen premature and 21 term neonates were treated with whole milligram doses of enoxaparin. The mean starting and therapeutic enoxaparin doses were 1.72±0.17 and 1.86±0.17 mg kg−1, respectively. Twenty-five (64%) reached therapeutic antifactor Xa (anti-Xa) levels with the starting dose, whereas 14 (36%) required dose adjustments. One neonate reached a supratherapeutic anti-Xa level (>1.0 IU ml−1) in the loading phase. No bleeding episodes occurred. The mean treatment duration was 12 weeks. Among 34 (85%) evaluable patients, 23 (68%) had a complete response, 9 (26%) partial and 2 (6%) had a stable thrombotic state.

Conclusion:

Whole milligram dosing of enoxaparin for thrombosis is feasible, safe and effective in premature and term neonates.

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Acknowledgements

No financial support was received for this study

Author information

Authors and Affiliations

  1. Division of Pediatric Hematology/Oncology, McMaster Children’s Hospital, McMaster University, Hamilton, ON, Canada

    R Goldsmith, A K Chan & M D Bhatt

  2. Division of Neonatology, McMaster Children’s Hospital, McMaster University, Hamilton, ON, Canada

    B A Paes

Authors
  1. R Goldsmith
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  2. A K Chan
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  3. B A Paes
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  4. M D Bhatt
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on behalf of the Thrombosis and Hemostasis in Newborns (THiN) Group

Corresponding author

Correspondence to M D Bhatt.

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The authors declare no conflict of interest.

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Goldsmith, R., Chan, A., Paes, B. et al. Feasibility and safety of enoxaparin whole milligram dosing in premature and term neonates. J Perinatol 35, 852–854 (2015). https://doi.org/10.1038/jp.2015.84

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