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Comparison of three types of intervention to enhance placental redistribution in term newborns: randomized control trial

Journal of Perinatology volume 35, pages 720–724 (2015)Cite this article

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Abstract

Objective:

To compare the effect of combined delayed cord clamping and umbilical cord milking to either of them had done alone, on hematological parameters at 6 weeks of age in term neonates.

Study design:

It was a randomized controlled trial, conducted during January to December 2014. Three hundred eligible neonates were randomly allocated to three parallel groups. Primary outcome was hemoglobin and serum ferritin at 6 weeks of age. Data were analyzed using analysis of variance and Kruskal–Wallis test.

Results:

Baseline characteristics and hemodynamic parameters were comparable in all the three groups. The median serum ferritin level at 6 weeks was significantly higher in the group receiving both delayed cord clamping and milking the cut cord group (295.49 (233.5 to 346.54) ng ml−1) as compared with the group that received only milking of the cut cord (184.55 (131.22 to 256.5) ng ml−1) or only delayed cord clamping (268.8 (189.4 to 315.44) ng ml−1).

Conclusion:

Delayed cord clamping with milking the cut cord improved iron stores at 6 weeks of age in term infants, then either of the two interventions alone.

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Acknowledgements

We thank the parents and resident doctors of Department of Pediatrics and Obstetrics for their valuable support. This study was also registered in Clinical Trial Registry of India (CTRI). CTRI/2014/10/005116.

Author information

Authors and Affiliations

  1. Department of Pediatrics, LLRM Medical College, Meerut, Uttar Pradesh, India

    A K Yadav, A Upadhyay & U Mandal

  2. Department of Pediatrics, SMS Medical College, Jaipur, Rajasthan, India

    S Gothwal

  3. Department of Obstetrics and Gynaecology, LLRM Medical College, Meerut, Uttar Pradesh, India

    K Dubey

  4. Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India

    C P Yadav

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  1. A K Yadav
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Correspondence to A Upadhyay.

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Yadav, A., Upadhyay, A., Gothwal, S. et al. Comparison of three types of intervention to enhance placental redistribution in term newborns: randomized control trial. J Perinatol 35, 720–724 (2015). https://doi.org/10.1038/jp.2015.65

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  • DOI: https://doi.org/10.1038/jp.2015.65

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