Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Maternal and fetal outcomes following unplanned conversion to general anesthetic at elective cesarean section

Abstract

Objective:

To investigate risk factors predicting unplanned conversion to general anesthesia during elective cesarean section, and to examine maternal and fetal outcomes associated with unplanned conversion compared with other modes of anesthesia.

Study Design:

A retrospective cohort at a UK center (2008 to 2013). Women (4337) underwent elective cesarean section. Delivery outcomes were compared according to anesthesia type using logistic regression.

Result:

Women (1.6%) underwent unplanned conversion to general anesthetic. Unplanned conversion was associated with higher parity (odds ratio (OR) 3.82, confidence interval (CI; (1.58 to 9.62)) and maternal age 40 (OR 4.40, CI (1.08 to 29.88)). Compared with spinal anesthetic, unplanned conversion was associated with increased likelihood of maternal hemorrhage 1.5 l (OR 5.74, CI (1.90 to 14.01)) and delayed neonatal respiration (OR 4.76, CI (1.76 to 11.05)). Adverse outcomes were not significantly more likely compared with planned general anesthetic.

Conclusion:

Higher parity and maternal age are risk factors for unplanned conversion to general anesthetic. There is no increase in the likelihood of adverse outcomes with unplanned versus planned general anesthetic.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Palanisamy A, Mitani AA, Tsen LC . General anesthesia for cesarean delivery at a tertiary care hospital from 2000 to 2005: a retrospective analysis and 10-year update. Int J Obstet Anesth 2011; 20: 10–16.

    Article  CAS  Google Scholar 

  2. Afolabi BB, Lesi FE . Regional versus general anaesthesia for caesarean section. Cochrane Database Syst Rev 2012; 10: CD004350.

    PubMed  Google Scholar 

  3. Heesen M, Hofmann T, Klohr S, Rossaint R, van de Velde M, Deprest J et al. Is general anaesthesia for caesarean section associated with postpartum haemorrhage? Systematic review and meta-analysis. Acta Anaesthesiol Scand 2013; 57: 1092–1102.

    Article  Google Scholar 

  4. Liberis V, Tsikouras P, Vogiatzaki T, Savidis A, Ammari A, Iatrou C et al. The contribution of anaesthesia modus on reducing blood loss during caesarean section. Clin Exp Obstet Gynecol 2009; 36: 105–109.

    CAS  PubMed  Google Scholar 

  5. Fassoulaki A, Petropoulos G, Staikou C, Siafaka I, Sarantopoulos C . General versus neuraxial anaesthesia for caesarean section: impact on the duration of hospital stay. J Obstet Gynaecol 2009; 29: 25–30.

    Article  CAS  Google Scholar 

  6. Havas F, Orhan Sungur M, Yenigun Y, Karadeniz M, Kilic M, Ozkan Seyhan T . Spinal anesthesia for elective cesarean section is associated with shorter hospital stay compared to general anesthesia. Agri 2013; 25: 55–63.

    Article  Google Scholar 

  7. Tsai PS, Hsu CS, Fan YC, Huang CJ . General anaesthesia is associated with increased risk of surgical site infection after Caesarean delivery compared with neuraxial anaesthesia: a population-based study. Br J Anaesth 2011; 107: 757–761.

    Article  Google Scholar 

  8. Algert CS, Bowen JR, Giles WB, Knoblanche GE, Lain SJ, Roberts CL . Regional block versus general anaesthesia for caesarean section and neonatal outcomes: a population-based study. BMC Med 2009; 7: 20.

    Article  Google Scholar 

  9. Mancuso A, De Vivo A, Giacobbe A, Priola V, Maggio Savasta L, Guzzo M et al. General versus spinal anaesthesia for elective caesarean sections: effects on neonatal short-term outcome. A prospective randomised study. J Matern Fetal Neonatal Med 2010; 23: 1114–1118.

    Article  Google Scholar 

  10. Lesage S . Cesarean delivery under general anesthesia: Continuing Professional Development. Can J Anaesth 2014; 61: 489–503.

    Article  Google Scholar 

  11. Reynolds F . General anesthesia is unacceptable for elective cesarean section. Int J Obstet Anesth 2010; 19: 212–217.

    Article  Google Scholar 

  12. Staikou C, Paraskeva A, Karmaniolou I, Mani A, Chondrogiannis K . Current practice in obstetric anesthesia: a 2012 European survey. Minerva Anestesiol 2014; 80: 347–354.

    CAS  PubMed  Google Scholar 

  13. Sng BL, Lim Y, Sia AT . An observational prospective cohort study of incidence and characteristics of failed spinal anaesthesia for caesarean section. Int J Obstet Anesth 2009; 18: 237–241.

    Article  CAS  Google Scholar 

  14. Kinsella SM . A prospective audit of regional anaesthesia failure in 5080 Caesarean sections. Anaesthesia 2008; 63: 822–832.

    Article  CAS  Google Scholar 

  15. Wilson SH, Fecho K, Marshall J, Spielman F . Factors influencing cesarean delivery operative times: a prospective observational cohort study. Int J Obstet Anesth 2010; 19: 417–421.

    Article  CAS  Google Scholar 

  16. Colvin JR, Peden CJ (eds). Raising the Standard: a Compendium of Audit Recipes. 3rd edn. The Royal College of Anaesthetists: London, UK, 2012.

    Google Scholar 

  17. George R, Kar G, Stacey R . Conversion from regional to general anaesthesia for caesarean section: we are meeting the standards!. Anaesthesia 2012; 67: 1279.

    Article  CAS  Google Scholar 

  18. Rafi MA, Arfeen Z, Misra U . Conversion of regional to general anaesthesia at caesarean section: increasing the use of regional anaesthesia through continuous prospective audit. Int J Obstet Anesth 2010; 19: 179–182.

    Article  CAS  Google Scholar 

  19. Joint Committee of the Royal College of Anaesthetists and the Royal College of Obstetricians and Gynaecologists. Classification of Urgency of Caesarean Section - A Continuum of Risk. 2010, Good Practice No. 11. Published by the Royal College of Obstetricians and Gynaecologists: London, UK.

  20. Yeh P, Emary K, Impey L . The relationship between umbilical cord arterial pH and serious adverse neonatal outcome: analysis of 51,519 consecutive validated samples. BJOG 2012; 119: 824–831.

    Article  CAS  Google Scholar 

  21. Gregory KD, Korst LM, Gornbein JA, Platt LD . Using administrative data to identify indications for elective primary cesarean delivery. Health Serv Res 2002; 37: 1387–1401.

    Article  Google Scholar 

  22. Peled Y, Melamed N, Chen R, Pardo J, Ben-Shitrit G, Yogev Y . The effect of time of day on outcome of unscheduled cesarean deliveries. J Matern Fetal Neonatal Med 2011; 24: 1051–1054.

    Article  Google Scholar 

  23. Loubert C, Fernando R . Cesarean delivery in the obese parturient: anesthetic considerations. Womens Health (Lond Engl) 2011; 7: 163–179.

    Article  Google Scholar 

  24. Rodrigues FR, Brandao MJ . Regional anesthesia for cesarean section in obese pregnant women: a retrospective study. Rev Bras Anestesiol 2011; 61: 13–20.

    Article  Google Scholar 

  25. Ozlu F, Yapicioglu H, Ulu B, Buyukkurt S, Unlugenc H . Do all deliveries with elective caesarean section need paediatrician attendance? J Matern Fetal Neonatal Med 2012; 25: 2766–2768.

    Article  Google Scholar 

Download references

Acknowledgements

Dr AR Aiken is supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development grant for Infrastructure for Population Research at Princeton University, grant R24HD047879.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to C E Aiken.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Aiken, C., Aiken, A., Cole, J. et al. Maternal and fetal outcomes following unplanned conversion to general anesthetic at elective cesarean section. J Perinatol 35, 695–699 (2015). https://doi.org/10.1038/jp.2015.62

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/jp.2015.62

This article is cited by

Search

Quick links