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Infants born at <29 weeks: pulmonary outcomes from a hybrid perinatal system

Journal of Perinatology volume 34, pages 59–63 (2014)Cite this article

Subjects

Abstract

Objective:

To assess pulmonary outcomes of infants <29 weeks gestational age (GA), delivered at level I, II and III facilities, to identify potentially modifiable factors affecting bronchopulmonary dysplasia (BPD) severity and to assess the external generalizability of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) BPD Outcome Estimator.

Study Design:

Outcomes for infants <29 weeks GA born during (2008–2010) and delivered either at an inborn level III center or in a level II or III metropolitan area hospital with transfer to a level IV center, or delivered in a distant level I or II center and then transported to a level IV center were assessed. BPD severity was compared with the NICHD Neonatal BPD Outcome Estimator.

Result:

Of 158 infants who comprised the cohort, 28 (17.8%) had no BPD, 39 (24.2%) had mild BPD, 45 (28.7%) had moderate BPD, 31 (19.7%) had severe BPD and 15 (9.6%) died at ⩽36 weeks post menstrual age. Site of birth did not predict severe BPD or death. Receiver operator characteristic curves showed fair predictability for none/mild and severe BPD.

Conclusion:

BPD severity was not dependent on site of birth. The NICHD BPD outcome estimator provides fair prediction for extreme outcomes.

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Acknowledgements

This study was supported by the Center for Infant Pulmonary Disorders, Children’s Mercy Hospitals and Clinics. The funding agency provided overall oversight for study conduct. All analyses and interpretation of the data and the preparation, review and approval of this manuscript were independent of the funding agency.

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Authors and Affiliations

  1. Department of Pediatrics, Children’s Mercy Hospitals and Clinics, Center for Infant Pulmonary Disorders, University of Missouri-Kansas City School of Medicine, Kansas, MO, USA

    W E Truog, M F Nyp, J Taylor, L L Gratny, H Escobar, W M Manimtim, C I Lachica, A Khmour, O O Oluola, A A Oshodi, M Norberg, H Dai & E K Pallotto

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  1. W E Truog
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Corresponding author

Correspondence to W E Truog.

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The authors declare no conflict of interest.

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Author Contributions

William E Truog, MD: Involved in study conception, hypotheses delineation and design, data acquisition, data analysis and interpretation, writing and revising the manuscript. Michael F. Nyp, DO: Involved in data acquisition, revising the manuscript. Jane Taylor, MD: Involved in data acquisition, revising the manuscript. Linda L Gratny, MD: Involved in data acquisition, revising the manuscript. Hugo Escobar, MD: Involved in data acquisition, revising the manuscript. Winston M Manimtim, MD: Involved in data acquisition, revising the manuscript. Charisse I Lachica, MD: Involved in data acquisition, revising the manuscript. Ayman Khmour, MD: Involved in data acquisition, revising the manuscript. Okunola O Oluola, MD: Involved in data acquisition, revising the manuscript. Adebayo A Oshodi, MD: Involved in data acquisition, revising the manuscript. Michael Norberg, BS, MDiv: Involved in study design, data acquisition, data design and analysis, writing and revising the manuscript. Hongying Dai, PhD: Involved in statistical analysis. Eugenia K Pallotto, MD, MSCE: Involved in hypotheses delineation, data analysis and interpretation, revising the manuscript.

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Truog, W., Nyp, M., Taylor, J. et al. Infants born at <29 weeks: pulmonary outcomes from a hybrid perinatal system. J Perinatol 34, 59–63 (2014). https://doi.org/10.1038/jp.2013.125

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