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Genetic associations of surfactant protein D and angiotensin-converting enzyme with lung disease in preterm neonates

Journal of Perinatology volume 32, pages 349–355 (2012)Cite this article

Abstract

Objective:

To replicate genetic associations with respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD) in genes related to surfactant deficiency, inflammation and infection, and the renin–angiotensin system.

Study Design:

We examined eight candidate genes for associations with RDS and BPD in 433 preterm birth (PTB—<37 weeks) infants (251 with RDS and 134 with BPD). Both case–control and family-based analyses were performed in preterm (<37 weeks) and very preterm birth (VPTB—<32 weeks) infants.

Result:

We replicated a previous finding that rs1923537, a marker downstream of surfactant protein D (SFTPD) is associated with RDS in VPTB infants in that the T allele was overtransmitted from parents to offspring with RDS (P=8.4 × 10−3). We also observed the A allele of rs4351 in the angiotensin-converting enzyme (ACE) gene was overtransmitted from parents to VPTB offspring with BPD (P=9.8 × 10−3).

Conclusion:

These results give further insight into the genetic risk factors for complex neonatal respiratory diseases and provide more evidence of the importance of SFTPD and ACE in the etiology of RDS and BPD, respectively.

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Acknowledgements

We would like to express our thanks to all the participating families in our study. We would also like to express our gratitude to the coordinating medical and research staff at the University of Iowa Children's Hospital in Iowa City, IA, USA; including a special thanks to research coordinators Susan Berends and Laura Knosp. Additionally, we would like to thank the research technician involved in genotyping and sample management including Tamara Busch and students Rim Halaby and Jad al Danaf. This work was supported by the March of Dimes (Grants 1-FY05-126 and 6-FY08-260) and the NIH (Grants R01 HD-52953 and R01 HD-57192). Dr. Ryckman's postdoctoral fellowship was supported by a NIH/NRSA T-32 training Grant (5T32 HL 007638-24).

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Authors and Affiliations

  1. Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, USA

    K K Ryckman, J M Dagle, K Kelsey, A M Momany & J C Murray

  2. Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA

    K Kelsey

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  1. K K Ryckman
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Correspondence to J C Murray.

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Ryckman, K., Dagle, J., Kelsey, K. et al. Genetic associations of surfactant protein D and angiotensin-converting enzyme with lung disease in preterm neonates. J Perinatol 32, 349–355 (2012). https://doi.org/10.1038/jp.2011.104

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