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Usefulness of the renal resistive index to predict an increase in urinary albumin excretion in patients with essential hypertension

Journal of Human Hypertension volume 31, pages 66–69 (2017)Cite this article

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Abstract

Microalbuminuria is a risk factor for cardiovascular events and death in hypertensive patients. Patients who are expected to increase albuminuria need strict blood pressure control. In the present study, we assessed the association between the renal resistive index (RI) and future increases in albuminuria in patients with essential hypertension. Sixty-six patients with essential hypertension were included in the study. Univariate and multivariate logistic regression analyses were used to identify the factors, including renal RI, that were significant independent determinants of increased in urinary albumin excretion (UAE), defined as an increase of >50% in the urinary albumin-to-creatinine ratio over 2 years. Receiver operator characteristics curve analysis was used to select the optimal cut-off point that predicted an increase in UAE. RI was the only significant variable that predicted the increase in UAE, with the optimal cut-off value of renal RI that predicted this increase being 0.71 (sensitivity 52.4% and specificity 84.4%). Renal RI is associated with the future increase in albuminuria in patients with essential hypertension.

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Authors and Affiliations

  1. Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine, Toon, Japan

    K Miyoshi, T Okura, A Tanino, M Kukida, T Nagao & J Higaki

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  1. K Miyoshi
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  2. T Okura
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  3. A Tanino
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  4. M Kukida
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  5. T Nagao
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  6. J Higaki
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Correspondence to K Miyoshi.

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Competing interests

Dr JH received research grants and speaker honoraria from Actelion Pharm. Jpn., Astellas Pharm. Inc., Beringer-Ingerheim Japan Co., Daiichi-Sankyo Inc., Sumitomo Dainippon Pharm., Kyowa Hakkoh Kirin Co., MSD Co., Mitsubishi Tanabe Co., Mochida Pharm Co. Ltd., Otsuka Pharm Co Ltd., Sanofi Aventis Co., Pfizer Health Care Inc., Shionogi Pharm Co. Ltd., Takeda Pharm. Co., Ltd. The remaining authors declare no conflicts of interest.

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Miyoshi, K., Okura, T., Tanino, A. et al. Usefulness of the renal resistive index to predict an increase in urinary albumin excretion in patients with essential hypertension. J Hum Hypertens 31, 66–69 (2017). https://doi.org/10.1038/jhh.2016.38

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  • DOI: https://doi.org/10.1038/jhh.2016.38

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