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CYP3A5 as a candidate gene for hypertension: no support from an unselected indigenous West African population

Journal of Human Hypertension volume 30, pages 778–782 (2016)Cite this article

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Abstract

CYP3A5 (cytochrome P450, family 3, subfamily A, polypeptide 5) expression stimulates the sodium retentive actions of the mineralocorticoid receptor causative of hypertension, probably by means of its ability to substantially increase the level of 6β-hydroxylase activity. Most Black individuals are functional CYP3A5 expressers, and this is a candidate gene for the high incidence of hypertension in Black populations. The study investigates whether CYP3A5 expression results in higher blood pressure in a Ghanaian population. Real-time PCR was used to genotype 898 DNA samples for the CYP3A5*3 and CYP3A5*6 single-nucleotide polymorphisms with technically adequate genotyping for 881 samples. Of these, 803 were genetic CYP3A5 expressers, 44 nonexpressers and 34 uncertain (CYP3A5*3/*6). Although there was a trend in the proportion of hypertensive individuals as CYP3A5 expression decreased, using a two-sided t-test, no statistically significant relationship was established between systolic or diastolic pressure and CYP3A5*3 or CYP3A5*6 genotypes, or their haplotypes (Systolic confidence interval: −8.44 to –7.70, P=0.93, Diastolic confidence interval: −4.89 to 4.85, P=0.99). We conclude, therefore, that there is either no association between CYP3A5 expression and blood pressure or, if there is a relationship, the strength of the association is very small.

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Acknowledgements

The original study was supported by a Wellcome Trust Project grant in 2000 (060415/Z/00/Z).

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Author notes

  1. D L Fisher

    Present address: 7Current address: Hinchingbrooke Health Care NHS Trust, Huntingdon, UK.,

Authors and Affiliations

  1. Analytical Services International Ltd, St George’s, University of London, London, UK

    D L Fisher, M Moreton & A Johnston

  2. School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

    J Plange-Rhule

  3. Komfo Anokye Teaching Hospital, Kumasi, Ghana

    J Plange-Rhule & F Micah

  4. Institute of Medical and Biomedical Education: Renal Medicine, St George’s, University of London, London, UK

    J B Eastwood & I A M MacPhee

  5. Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

    S M Kerry

  6. Division of Mental Health & Wellbeing, University of Warwick, Warwick Medical School, Coventry, UK

    F P Cappuccio

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  1. D L Fisher
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Correspondence to I A M MacPhee.

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Fisher, D., Plange-Rhule, J., Moreton, M. et al. CYP3A5 as a candidate gene for hypertension: no support from an unselected indigenous West African population. J Hum Hypertens 30, 778–782 (2016). https://doi.org/10.1038/jhh.2016.25

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  • DOI: https://doi.org/10.1038/jhh.2016.25

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