Abstract
Psychological disturbances, including anxiety and depression, are common during human pregnancy. Our objective was to determine whether these maternal disturbances influence cardiovascular responses of the offspring. The psychological status of 231 pregnant women was determined. Offspring (216) of these women were subsequently exposed to a video challenge stress when aged 7–9 years. Heart rate (HR) and blood pressure (BP) of the children were determined at rest, in response to video stress and during subsequent recovery. Children’s resting and stress-induced increases in HR (bpm), systolic (SBP, mm Hg) and diastolic (DBP, mm Hg) BP were all greater in children whose mothers reported anxiety during pregnancy. Values (mean±s.d.) for resting HR, SBP and DBP were 75.15±5.87, 95.37±2.72 and 66.39±4.74 for children whose mothers reported no anxiety and an average of 81.62±6.71, 97.26±2.90 and 68.86±2.82 for children whose mothers reported anxiety at any level. Respective values for stress-induced increments in HR, SBP and DBP were 14.83.±2.14, 16.41±1.97 and 12.72±2.69 for children whose mothers reported no anxiety and 17.95±3.46, 18.74±2.46 and 14.86±2.02 for children whose mothers reported any level of anxiety. Effects of maternal depression were less consistent. The effects of maternal anxiety remained in multivariate analyses, which also included children’s birth weight. The results indicate a long-term influence of maternal psychological status during pregnancy on the cardiovascular responses to stress among offspring. These effects may contribute to prenatal influences on subsequent health of the offspring.
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References
Barker DJ, Winter PD, Osmond C, Margetts B, Simmonds SJ . Weight in infancy and death from ischaemic heart disease. Lancet 1989; 2 (8663): 577–580.
Lackland DT, Egan BM, Ferguson PL . Low birth weight as a risk factor for hypertension. J Clin Hypertens 2003; 5 (2): 133–136.
Mastorci F, Vicentini M, Viltart O, Manghi M, Graiani G, Quaini F et al. Long-term effects of prenatal stress: changes in adult cardiovascular regulation and sensitivity to stress. Neurosci Biobehav Rev 2009; 33 (2): 191–203.
Chen W, Srinivasan SR, Yao L, Li S, Dasmahapatra P, Fernandez C et al. Low birth weight is associated with higher blood pressure variability from childhood to young adulthood: the Bogalusa Heart Study. Am J Epidemiol 2012; 176 (Suppl 7): S99–105.
de Jong F, Monuteaux MC, van Elburg RM, Gillman MW, Belfort MB . Systematic review and meta-analysis of preterm birth and later systolic blood pressure. Hypertension 2012; 59 (2): 226–234.
Law CM, Shiell AW . Is blood pressure inversely related to birth weight? The strength of evidence from a systematic review of the literature. J Hypertens 1996; 14 (8): 935–941.
Pereira JA, Rondo PH, Lemos JO, Pacheco de Souza JM, Dias RS . The influence of birthweight on arterial blood pressure of children. Clin Nutr 2010; 29 (3): 337–340.
Chen X, Wang Y . Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysis. Circulation 2008; 117 (25): 3171–3180.
Juhola J, Magnussen CG, Viikari JS, Kahonen M, Hutri-Kahonen N, Jula A et al. Tracking of serum lipid levels, blood pressure, and body mass index from childhood to adulthood: the Cardiovascular Risk in Young Finns Study. J Pediatrics 2011; 159 (4): 584–590.
Markovitz JH, Raczynski JM, Wallace D, Chettur V, Chesney MA . Cardiovascular reactivity to video game predicts subsequent blood pressure increases in young men: the CARDIA study. Psychosom Med 1998; 60 (2): 186–191.
Chen W, Srinivasan SR, Ruan L, Mei H, Berenson GS . Adult hypertension is associated with blood pressure variability in childhood in blacks and whites: the bogalusa heart study. Am J Hypertens 2011; 24 (1): 77–82.
Matthews KA, Salomon K, Brady SS, Allen MT . Cardiovascular reactivity to stress predicts future blood pressure in adolescence. Psychosom Med 2003; 65 (3): 410–415.
Matthews KA, Woodall KL, Allen MT . Cardiovascular reactivity to stress predicts future blood pressure status. Hypertension 1993; 22 (4): 479–485.
Woods SM, Melville JL, Guo Y, Fan MY, Gavin A . Psychosocial stress during pregnancy. Am J Obstet Gynecol 2010; 202 (1): 61 e61–61 e67.
Gou W-L, Wu LF . Delivery Science [in Chinese]. 1st Editorial Beijing. republic Health Press: China, 2003, 625–628.
Heron J, O'Connor TG, Evans J, Golding J, Glover V, Team AS . The course of anxiety and depression through pregnancy and the postpartum in a community sample. J Affect Disord 2004; 80 (1): 65–73.
Faisal-Cury A, Rossi Menezes P . Prevalence of anxiety and depression during pregnancy in a private setting sample. Arch Women's Ment Health 2007; 10 (1): 25–32.
Kurki T, Hiilesmaa V, Raitasalo R, Mattila H, Ylikorkala O . Depression and anxiety in early pregnancy and risk for preeclampsia. Obstet Gynecol 2000; 95 (4): 487–490.
Ross LE, McLean LM . Anxiety disorders during pregnancy and the postpartum period: a systematic review. J Clin Psychiatry 2006; 67 (8): 1285–1298.
van Dijk AE, van Eijsden M, Stronks K, Gemke RJ, Vrijkotte TG . Prenatal stress and balance of the child's cardiac autonomic nervous system at age 5-6 years. PloS ONE 2012; 7 (1): e30413.
Murphy JK, Alpert BS, Walker SS, Willey ES . Race and cardiovascular reactivity. A replication. Hypertension 1988; 11 (4): 308–311.
Kramer MS . Determinants of low birth weight: methodological assessment and meta-analysis. Bull World Health Organ 1987; 65 (5): 663–737.
Lobel M, Dunkel-Schetter C, Scrimshaw SC . Prenatal maternal stress and prematurity: a prospective study of socioeconomically disadvantaged women. Health Psychol 1992; 11 (1): 32–40.
Wadhwa PD, Sandman CA, Porto M, Dunkel-Schetter C, Garite TJ . The association between prenatal stress and infant birth weight and gestational age at birth: a prospective investigation. Am J Obstet Gynecol 1993; 169 (4): 858–865.
Li Q, Hsia J, Yang G . Prevalence of smoking in China in 2010. N Engl J Med 2011; 364 (25): 2469–2470.
UNICEF, WHO. Low birthweight. Country, regional and global estimates. UNICEF and WHO New York 2004, 1–31 December 2004.
Drake AJ, Tang JI, Nyirenda MJ . Mechanisms underlying the role of glucocorticoids in the early life programming of adult disease. Clin Sci (Lond) 2007; 113 (5): 219–232.
O'Connor TG, Ben-Shlomo Y, Heron J, Golding J, Adams D, Glover V . Prenatal anxiety predicts individual differences in cortisol in pre-adolescent children. Biol Psychiatry 2005; 58 (3): 211–217.
Schneider ML CA, Dejesus OT, Moore CF . Prenatal stress influences on neurobehavior, stress reactivity, and dopaminergic function in rhesus macaques. Primate models of Childrens Health and Development Disabilities. Academic Press/Elservier: New York, NY, USA, 2008, 231–258.
de Vries A, Holmes MC, Heijnis A, Seier JV, Heerden J, Louw J et al. Prenatal dexamethasone exposure induces changes in nonhuman primate offspring cardiometabolic and hypothalamic-pituitary-adrenal axis function. J Clin Invest 2007; 117 (4): 1058–1067.
Brummelte S, Galea LA . Depression during pregnancy and postpartum: contribution of stress and ovarian hormones. Prog Neuropsychopharmacol Biol Psychiatry 2010; 34 (5): 766–776.
Dunkel Schetter C, Tanner L . Anxiety, depression and stress in pregnancy: implications for mothers, children, research, and practice. Curr Opin Psychiatry 2012; 25 (2): 141–148.
Baker S, Chebli M, Rees S, Lemarec N, Godbout R, Bielajew C . Effects of gestational stress: 1. Evaluation of maternal and juvenile offspring behavior. Brain Res 2008; 1213: 98–110.
Marcus SM . Depression during pregnancy: rates, risks and consequences—Motherisk Update 2008. Can J Clin Pharmacol 2009; 16 (1): e15–e22.
Acknowledgements
We greatly thank all the participants and their families for their participation in this study. The work was supported, in part, by the 2010 Primary Scientific Research Foundation of Xi’an Jiaotong University and National Nature Science Foundation of China (NSFC81170294).
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Fan, F., Zou, Y., Tian, H. et al. Effects of maternal anxiety and depression during pregnancy in Chinese women on children’s heart rate and blood pressure response to stress. J Hum Hypertens 30, 171–176 (2016). https://doi.org/10.1038/jhh.2015.64
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DOI: https://doi.org/10.1038/jhh.2015.64
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