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Aldehyde dehydrogenase 2 as a potential protective factor for renal insufficiency in Japanese subjects with heart failure: a pilot study

Journal of Human Hypertension volume 28, pages 279–281 (2014)Cite this article

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The association between the aldehyde dehydrogenase 2 (ALDH2 , rs671) genotypes and the estimated glomerular filtration rate (eGFR) was investigated in Japanese hypertensive patients with/without coronary artery disease or with ischemic heart failure (HF), and age/sex-matched normotensive healthy controls. The eGFRs were significantly lower in the HF subjects with the ALDH2 *2/*2 genotype than in those with the other genotypes. Multiple regression analyses adjusted by the potentially confounding factors showed the *2/*2 genotype to be significantly associated with the decreased eGFR, compared to the *1/*1 genotype ( β =−31.99 ml min−1 per 1.73 m2, P <0.01).

Systemic endothelial dysfunction is an underlying pathological mechanism for the onset and progression of cardiac and renal insufficiency in patients with a hypertensive status.1, 2, 3, 4, 5 Endothelial dysfunction also involves systemic blood vessels in the majority of patients with an ischemic etiology of heart failure (HF).4 Aldehyde dehydrogenase 2 (ALDH2) is the primary enzyme that detoxifies various toxic aldehydes in a range of organs and cell types, and prevents the oxidative injury cascade that leads to widespread endothelial dysfunction, inflammation and/or cell death.6, 7

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Acknowledgements

This work was supported by KAKENHI (no. 23510348) and by a grant from the Smoking Research Foundation.

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Authors and Affiliations

  1. Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan

    K Morita, K Oniki, H Miyazaki, J Saruwatari & K Nakagawa

  2. Japanese Red Cross Kumamoto Health Care Center, Kumamoto, Japan

    Y Ogata

  3. Department of Cardiovascular Medicine, Faculty of Life Sciences, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

    M Mizobe, M Yamamuro, S Hokimoto & H Ogawa

  4. Center for Clinical Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan

    K Nakagawa

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  1. K Morita
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Correspondence to K Nakagawa.

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Morita, K., Oniki, K., Miyazaki, H. et al. Aldehyde dehydrogenase 2 as a potential protective factor for renal insufficiency in Japanese subjects with heart failure: a pilot study. J Hum Hypertens 28, 279–281 (2014). https://doi.org/10.1038/jhh.2013.90

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