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Relationship between paraoxonase-1 activity, carotid intima-media thickness and arterial stiffness in hypertensive patients

Journal of Human Hypertension volume 24, pages 492–494 (2010)Cite this article

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Low paraoxonase-1 (PON1) activity has been regarded as one of risk factors for cardiovascular disease. We showed that low PON1 activity was independently associated with carotid intima-media thickness (IMT) and heart to femoral pulse wave velocity (hfPWV) in hypertensive patients. Our results indicate that PON1 activity may reflect early structural and functional changes of arteries in this population.

High-density lipoprotein has well-known protective effects against atherosclerosis, aiding reverse cholesterol transport from the artery wall and protecting low-density lipoprotein (LDL) against oxidation.1 The antioxidant mechanisms of high-density lipoprotein have been intensely studied, leading to the identification of paraoxonase-1 (PON1) as one of the major contributors.2 PON1 prevents LDL oxidation by reducing lipid peroxides, enhances cholesterol efflux from macrophages and interrupts foam cell formation by suppressing oxidized LDL uptake by macrophages.2 Some studies have reported that low PON1 activity could be one of the risk factors for cardiovascular disease. It has been further shown that reduced serum concentrations and activity of PON1 in patients with coronary artery disease relate to the severity of the disease.3 In this study, we sought to identify a relationship between PON1 activity and carotid IMT, a surrogate marker of early atherosclerosis, in hypertensive patients. In addition, we evaluated the association between PON1 activity and arterial stiffness.

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Acknowledgements

This study was supported by a grant (A000385) from the Ministry of Health and Welfare, Republic of Korea, a grant from the Seoul R&BD Program, Republic of Korea (10526) and a grant from the Korean Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A085136).

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Authors and Affiliations

  1. Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea

    W-I Yang, S-H Lee, Y-G Ko, S-M Kang, D Choi, J-W Ha, M-K Hong, N Chung, W-H Shim, S-Y Cho & Y Jang

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  1. W-I Yang
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Correspondence to S-H Lee.

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Yang, WI., Lee, SH., Ko, YG. et al. Relationship between paraoxonase-1 activity, carotid intima-media thickness and arterial stiffness in hypertensive patients. J Hum Hypertens 24, 492–494 (2010). https://doi.org/10.1038/jhh.2010.10

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