Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Echocardiography in clinical practice: the burden of arterial hypertension. A multicenter Italian survey

Abstract

Little information is available about the burden of hypertension on echo-lab activity in current practice. The aim of the present nation-wide survey in outpatient echo-labs was to investigate the prevalence rates of (1) echo examinations performed for the evaluation of hypertensive cardiac damage; (2) reports providing quantitative data on left ventricular (LV) structure and geometry; (3) LV hypertrophy (LVH) in hypertensives referred to echo labs. The study was carried out in 14 outpatient echo-labs across Italy. Prescriptions written by general practitioners were used to identify the indications for the examinations. Estimates of LVH were derived from original echo reports or were calculated from LV primary measures, when available, with Devereux's formula in a post-analysis. Echo examination was performed in 2449 subjects (1245 men and 1204 women); hypertension was the indication for echo in 745 (30.4%) cases. In this subgroup, LV mass (LVM), LVM indexed to body surface area, LVM indexed to height2.7 and relative wall thickness ratio were reported in 58, 59, 54 and 52%, respectively. LVH was present in 53% of untreated hypertensives and, among treated patients, in 45 and 65% of those with and without blood pressure control, respectively. Our findings show that (1) hypertension accounts for approximately one-third of echo examinations performed in clinical practice; (2) a large fraction of echo reports do not provide quantitative data on LVM and LV geometry, (3) LVH is highly prevalent in hypertensives referred to echo labs for assessment of cardiac damage.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3

Similar content being viewed by others

References

  1. Ruilope LM, Schmieder RE . Left ventricular hypertrophy and clinical outcomes in hypertensive patients. Am J Hypertens 2008; 21: 500–508.

    Article  Google Scholar 

  2. Schmieder RE . The role of non-haemodynamic factors in the genesis of LVH. Nephron Dial Transplant 2005; 20: 2610–2612.

    Article  Google Scholar 

  3. Koren MJ, Devereux RB, Casale PN, Savage DD, Laragh JH . Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension. Ann Intern Med 1991; 114: 345–352.

    Article  CAS  Google Scholar 

  4. Vakili BA, Okin PM, Devereux RB . Prognostic implications of left ventricular hypertrophy. Am Heart J 2001; 141: 334–341.

    Article  CAS  Google Scholar 

  5. Taylor HA, Penman AD, Han H, Dale-Michael A, Sketon TN, Fox ER et al. Left ventricular architecture and survival in African-Americans free of coronary heart disease (from the Atherosclerosis Risk in Communities [ARIC] study). Am J Cardiol 2007; 99: 1413–1420.

    Article  Google Scholar 

  6. Koren MJ, Ulin RJ, Laragh JH, Devereux RB . Reduction of left ventricular mass during treatment of essential hypertension is associated with improved prognosis. Am J Hypertens 2002; 15: 1021–1028.

    Article  Google Scholar 

  7. Devereux RB, Wachtell K, Gerdts E, Boman K, Nieminen MS, Papademetriou V et al. Prognostic significance of left ventricular mass change during treatment of hypertension. JAMA 2004; 292: 2350–2356.

    Article  CAS  Google Scholar 

  8. Muiesan ML, Salvetti M, Monteduro C, Bonzi B, Paini A, Viola S et al. Left ventricular concentric geometry during treatment adversely affects cardiovascular prognosis in hypertensive patients. Hypertension 2004; 43: 731–738.

    Article  CAS  Google Scholar 

  9. Verdecchia P, Angeli F, Gattobigio R, Sardone M, Pede S, Reboldi GP . Regression of left ventricular hypertrophy and prevention of stroke in hypertensive subjects. Am J Hypertens 2006; 19: 493–499.

    Article  Google Scholar 

  10. de Simone G, Devereux RB, Koren MJ, Mensah GA, Casale PN, Laragh JH . Midwall left ventricular mechanics: an independent predictor of cardiovascular risk in hypertension. Circulation 1996; 95: 259–265.

    Article  Google Scholar 

  11. Jennings GLR, McMullen JR . Left ventricular hypertrophy: beyond the image and defining the human cardiac phenotype in hypertension. J Hypertens 2007; 25: 941–947.

    Article  CAS  Google Scholar 

  12. Di Tullio MR, Sacco RL, Sciacca RR, Homma S . Left atrial size and the risk of ischemic stroke in an ethnically mixed population. Stroke 1999; 30: 2019–2024.

    Article  CAS  Google Scholar 

  13. Guidelines for the Management of Arterial Hypertension. The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007; 25: 1105–1187.

    Article  Google Scholar 

  14. Lavie CJ, Milani RV, Ventura HO, Messerli FH . Left ventricular geometry and mortality in patients >70 years of age with normal ejection fraction. Am J Cardiol 2006; 98: 1396–1399.

    Article  Google Scholar 

  15. Cuspidi C, Ambrosioni E, Mancia G, Pessina AC, Trimarco B, Zanchetti A, on behalf of the APROS Investigators. Role of echocardiography and carotid ultrasonography in stratifying risk in patients with essential hypertension: the Assessment of Prognostic Risk Observational Survey. J Hypertens 2002; 20: 1307–1314.

    Article  CAS  Google Scholar 

  16. Schillaci G, de Simone G, Reboldi GP, Porcellati C, Devereux RB, Verdecchia P . Change in cardiovaascular risk profile by echocardiography in low- or medium-risk hypertensives. J Hypertens 2002; 20: 1519–1525.

    Article  CAS  Google Scholar 

  17. Martinez MA, Sancho T, Armada E, Rubio JM, Antòn JL, Torre A et al. Prevalence of left ventricular hypertrophy in patients with mild hypertension in primary care: impact of echocardiography on cardiovascular risk stratification. Am J Hypertens 2003; 16: 556–563.

    Article  Google Scholar 

  18. Cuspidi C, Meani S, Valerio C, Fusi V, Sala C, Zanchetti A . Left ventricular hypertrophy and cardiovascular risk stratification: impact and cost-effectiveness of echocardiography in recently diagnosed hypertensives. J Hypertens 2006; 24: 1671–1677.

    Article  CAS  Google Scholar 

  19. Martina B, Nordmann A, Dieterle T, Sigle JP, Bengel G, Kiefer G et al. Impact of baseline echocardiography on treatment outcome in primary care patients with newly detected arterial hypertension: a randomized trial. Am J Hypertens 2006; 19: 1150–1155.

    Article  Google Scholar 

  20. Devereux RB, Reichek N . Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. Circulation 1977; 55: 613–618.

    Article  CAS  Google Scholar 

  21. Zanchetti A, Cuspidi C, Comarella L, Agabiti-Rosei E, Ambrosioni E, Chiariello M et al. Left ventricular diastolic dysfunction in elderly hypertensives: results from the APROS-diadys Study. J Hypertens 2007; 25: 2158–2167.

    Article  CAS  Google Scholar 

  22. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al., Chamber Quantification Writing Group; American Society of Echocardiography's Guidelines and Standards Committee; European Association of Echocardiography. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 2005; 18: 1440–1463.

    Article  Google Scholar 

  23. Agabiti-Rosei E, de Simone G, Mureddu G, Trimarco B, Verdecchia P, Volpe M, Joint Committee of the Italian Society of Hypertension (SIIA), Italian Society of Cardiology (SIC), Associazione Nazionale Medici Cardiologici Ospedalieri (ANMCO). Arterial hypertension and cardiac damage. Diagnostic and therapeutic guidelines. High Blood Press Cardiovasc Prev 2008; 3: 141–170.

    Article  Google Scholar 

  24. Cuspidi C, Valerio C, Sala C, Muiesan ML, Grandi AM, Palumbo G, et al., on behalf of the Lombardy Regional Section of the Italian Society of Hypertension. The Hyper-Pract Study: A multicentre survey on the accuracy of the echocardiographic assessment of hypertensive left ventricular hypertrophy in clinical practice. Blood Press 2008; 17: 124–128.

    Article  Google Scholar 

  25. Devereux RB, Casale PN, Kligfield P, Eisemberg RR, Miller D, Campo E et al. Performance of primary and derived M-mode echocardiographic measurements for detection of left ventricular hypertrophy in necropsied subjects and in patients with systemic hypertension, mitral regurgitation and dilated cardiomyopathy. Am J Cardiol 1986; 57: 1388–1393.

    Article  CAS  Google Scholar 

  26. Leibowitz D, Planer D, Ben-Ibgi F, Rott D, Weiss AT, Bursztyn M . Measurement of wall thickness alone does not accurately assess the presence of left ventricular hypertrophy. Clin Exp Hypertens 2007; 29: 119–125.

    Article  Google Scholar 

  27. Aurigemma GP, Gottdiener JS, Shemanski L, Gardin J, Kizman D . Predictive value of systolic and diastolic function for incident congestive heart failure in the elderly. The Cardiovascular Health Study. J Am Coll Cardiol 2001; 37: 1042–1048.

    Article  CAS  Google Scholar 

  28. Alfakih K, Reid S, Hall A, Sivananthan MU . The assessment of left ventricular hypertrophy in hypertension. J Hypertens 2006; 24: 1223–1230.

    Article  CAS  Google Scholar 

  29. Mancia G, Carugo S, Grassi G, Lanzarotti A, Schiavina S, Cesana G et al. Prevalence of left ventricular hypertrophy in hypertensive patients without and with blood pressure control. Data from the PAMELA population. Hypertension 2002; 39: 744–749.

    Article  CAS  Google Scholar 

  30. Cuspidi C, Meani S, Valerio C, Sala C, Fusi V, Zanchetti A et al. Age and target organ damage in essential hypertension: role of the metabolic syndrome. Am J Hypertens 2007; 20: 296–303.

    Article  CAS  Google Scholar 

  31. Coca A, Gabriel R, de la Figuera M, Lopez-Sendon JL, Fernandez R, Sagastagoitia JD et al. on behalf of the VITAE Investigators. The impact of different echocardiographic diagnostic criteria on the prevalence of left ventricular hypertrophy in essential hypertension: the VITAE study. J Hypertens 1999; 17: 1471–1480.

    Article  CAS  Google Scholar 

  32. de Simone G, Kizer JR, Chinali M, Roman MJ, Best LG, Lee ET et al. Normalization for body size and population-attributable risk of left ventricular hypertrophy. The Strong Heart Study. Am J Hypertens 2005; 18: 191–196.

    Article  Google Scholar 

Download references

Acknowledgements

The work was supported by a grant from the Italian Society of Hypertension.

Author information

Authors and Affiliations

Authors

Consortia

Corresponding author

Correspondence to C Cuspidi.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Appendix

Appendix

List of investigators

Bonanomi C, Settimi E, Danzi GB. Divisione di Cardiologia; IRCCS, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano; Branzi G, Lonati L, Parati G. Divisione di Cardiologia Ospedale San Luca, Istituto Auxologico Italiano, Milano; Capra A, Giannattasio C, Trocino G, Casati A. Dipartimento di Medicina Clinica e Prevenzione e Clinica Medica Generale, Divisione di Cardiologia, Ospedale San Gerardo, Monza; Chiappa L, Paggi A, Morganti A. UO Medicina Generale e Servizio di Cardiologia Ospedale S Giuseppe e Università degli Studi di Milano; Longo M, Valerio C, Marconi M. Centro Trasfusionale e di Immunoematologia Fondazione Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, Milano; Macca G. UO Cardiologia Clinica San Carlo, Paderno Dugnano; Milan A. Dipartimento di Medicina ed Oncologia Sperimentale, Divisione di Medicina Interna, Universita' di Torino; Negri F, Giudici V, Re A, Cuspidi C. Istituto Auxologico Italiano, Meda; Pellizzoli S, Robustelli F. Divisione di Cardiologia, Ospedale di Morbegno; Rao MAE, Iovino GL, Arcucci O, N De Luca Dipartimento di Medicina Clinica e Scienze Cardiovascolari, Università degli Studi ‘Federico II’, Napoli; Salvetti M, Paini A, Galbassini G. Dipartimento di Scienze Mediche e Chirurgiche, Universita' di Brescia; Tocci G, Ciavarella M, Volpe M. Unita' Operativa Complessa di Cardiologia, II Facolta' di Medicina e Chirurgia, Universita' La Sapienza, Roma; Vaccarella A. Servizio di Cardiologia- Presidio Operativo e di Ricerca di Casatenovo I.N.R.C.A-IRCCS; Veglia MG. UO Cardiologia Ospedale Madonna delle Grazie, Matera.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cuspidi, C., Negri, F., Giudici, V. et al. Echocardiography in clinical practice: the burden of arterial hypertension. A multicenter Italian survey. J Hum Hypertens 24, 395–402 (2010). https://doi.org/10.1038/jhh.2009.78

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/jhh.2009.78

Keywords

This article is cited by

Search

Quick links