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High serum levels of CXC chemokine ligand 10 in untreated essential hypertension

Journal of Human Hypertension volume 22, pages 579–581 (2008)Cite this article

The aim of the study was to evaluate the influence of high values of blood pressure on circulating CXCL10. CXCL10 levels (median; interquartile range (IQR)) were significantly higher in patients with high systolic and diastolic blood pressure ( n =48; 159 (125–185) pg ml−1) than in controls ( n =127; 98 (71–115) pg ml−1) or in patients with only systolic hypertension ( n =79; 125 (84–187) pg ml−1) (P <0.0001); in multiple linear regression models using CXCL10 as dependent variable, and age and systolic or diastolic blood pressure as covariates, only systolic or diastolic blood pressures were significantly ( P <0.0001) related to CXCL10 levels. The results of this study demonstrate increased serum CXCL10 levels in patients with hypertension.

Recent experimental evidence demonstrating that inflammation is involved in the initiation and development of hypertension has lead to the response-to-injury hypothesis of atherosclerosis.1, 2, 3 Furthermore, chemokines have been involved in the formation of atherosclerotic lesions in humans.4 It is known that hypertension exerts a proinflammatory action by increasing free-radical formation, leukocyte adhesion and chemokine production by the endothelium.1 In fact, patients with mild to moderate arterial hypertension without coronary artery disease have elevated serum levels of CC (group of chemokines with adjacent cysteines) chemokines MCP-1, MIP-1α and regulated on activation, normal T cell-expressed and secreted (RANTES).5

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Authors and Affiliations

  1. Department of Internal Medicine, Metabolism Unit, School of Medicine, University of Pisa, Pisa, Italy

    A Antonelli, P Fallahi, S M Ferrari & E Ferrannini

  2. Department of Clinical Pathophysiology, Endocrinology Unit, University of Florence, Florence, Italy

    M Rotondi, P Romagnani & M Serio

  3. Department of Internal Medicine, Hypertension Unit, School of Medicine, University of Pisa, Pisa, Italy

    L Ghiadoni & S Taddei

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  1. A Antonelli
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  9. E Ferrannini
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Correspondence to A Antonelli.

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Antonelli, A., Fallahi, P., Rotondi, M. et al. High serum levels of CXC chemokine ligand 10 in untreated essential hypertension. J Hum Hypertens 22, 579–581 (2008). https://doi.org/10.1038/jhh.2008.15

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