Abstract
We report here 20 single nucleotide polymorphisms (SNPs), including 10 novel ones, and their allelic frequencies detected in four genes that are known to be responsible for familial long QT syndrome in the Japanese population; 7 polymorphisms are in the KCNQ1 gene, 6 in the KCNH2 gene, 5 in the SCN5A gene, and 2 in the KCNE1 gene. These data will be of use for genetic association studies of acquired cardiac arrhythmias.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Additional information
Received: December 25, 1999 / Accepted: December 27, 1999
Rights and permissions
About this article
Cite this article
Iwasa, H., Itoh, T., Nagai, R. et al. Twenty single nucleotide polymorphisms (SNPs) and their allelic frequencies in four genes that are responsible for familial long QT syndrome in the Japanese population. J Hum Genet 45, 182–183 (2000). https://doi.org/10.1007/s100380050207
Published:
Issue Date:
DOI: https://doi.org/10.1007/s100380050207
This article is cited by
-
Genetics can contribute to the prognosis of Brugada syndrome: a pilot model for risk stratification
European Journal of Human Genetics (2013)
-
Cardiac channelopathy causing sudden death as revealed by molecular autopsy
International Journal of Legal Medicine (2013)
-
Detection of genetic variation in KCNQ1 gene by high-resolution melting analysis in a prospective-based series of postmortem negative sudden death: comparison of results obtained in fresh frozen and formalin-fixed paraffin-embedded tissues
International Journal of Legal Medicine (2012)
-
Association of KCNQ1, KCNE1, KCNH2 and SCN5A polymorphisms with QTc interval length in a healthy population
European Journal of Human Genetics (2005)
-
Denaturing high-performance liquid chromatography screening of the long QT syndrome-related cardiac sodium and potassium channel genes and identification of novel mutations and single nucleotide polymorphisms
Journal of Human Genetics (2005)