Abstract
Caspase-activated DNase (CAD) cleaves chromosomal DNA during apoptosis. We determined its genomic structure and identified single-nucleotide polymorphisms (SNPs) within exons 5 and 7, as well as a highly polymorphic dinucleotide repeat of (CT)m(CA)n within the 5′ region of the human CAD gene (hCAD). The genomic structure of hCAD presented here, together with information concerning SNPs within the gene, as well as a highly polymorphic (CT)m(CA)n repeat fragment at the hCAD locus, may assist in the construction of genetic maps for exploring gene(s) that play pivotal roles in carcinogenesis.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Additional information
Received: July 30, 1999 / Accepted: August 14, 1999
Rights and permissions
About this article
Cite this article
Sugimoto, N., Fukuda, Y., Saito-Ohara, F. et al. The human caspase-activated DNase gene (hCAD): genomic structure, exonic single-nucleotide polymorphisms, and a highly polymorphic dinucleotide repeat at the hCAD locus. J Hum Genet 44, 408–411 (1999). https://doi.org/10.1007/s100380050188
Published:
Issue Date:
DOI: https://doi.org/10.1007/s100380050188