Abstract
We found a novel polymorphism C/T change at position -34 counting from the first ATG codon, of the interleukin-4 (IL-4) gene, located between the TATA box and the first ATG on exon 1. The allelic frequency of this C/T polymorphism in 64 independent Japanese samples was 0.37 : 0.63. In addition, PCR-restriction fragment length polymorphism analysis revealed that the -34T/T polymorphism was always associated with -590T/T, a known polymorphism that increases IL-4 transcriptional activity.
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Received: March 8, 1999 / Accepted: April 12, 1999
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Takabayashi, A., Ihara, K., Sasaki, Y. et al. Novel polymorphism in the 5′-untranslated region of the interleukin-4 gene. J Hum Genet 44, 352–353 (1999). https://doi.org/10.1007/s100380050176
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DOI: https://doi.org/10.1007/s100380050176
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