Summary
Restriction fragment length polymorphisms were studied among the Japanese population using 12 polymorphic DNA probes on the q24–q28 region of X chromosome. The frequency distribution for probes p22–33, p482.6a, p43–15, 52A, pPM101, cX33.2 and cpx234, was the same as that for Caucasians, and that for probes 4D-8 and St14-1 (MspI) was slightly different (p<0.05). However, it was quite different (p<0.01) for probes p114.12, St14-1 (TaqI), 36B-2 and MN12. Probe p114.12 showed noHindIII polymorphism for the Japanese people. On the contrary, probe MN12, which has a low PIC value (0.15) for Caucasians, was found to be useful for Japanese (PIC value=0.50). These results suggest that 7 DNA probes (p482.6a, p43–15, 52A, St14-1, p114.12 (BclI), 36B-2 and MN12) are useful (PIC>0.42) for linkage analysis of X-linked disease in Japan.
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Antonarakis, S.E., Waber, P.G., Kittur, S.D., Patel, A.S., Kazazian, H.H., Mellis, M.A., Counts, R.B., Stamatoyannopoulos, G., Bowie, E.J.W., Fass, D.N., Pittman, D.D., Wozney, J.M. and Toole, J.J. 1985. Hemophilia A. Detection of molecular defects and carriers by DNA analysis.New Engl. J. Med. 313: 842–848.
Aubourg, P.R., Sack, G.H., Meyers, D.A., Lease, J.J. and Moser, H.W. 1987. Linkage of adrenoleukodystrophy to a polymorphic DNA probe.Ann. Neurol. 21: 349–352.
Gitschier, J., Drayna, D., Tuddenham, E.G.D., White, R.L. and Lawn, R.M. 1985. Genetic mapping and diagnosis of hemophilia A achieved through aBclI polymorphism in the factor VIII gene.Nature 314: 738–740.
Guesella, J.F., Wexler, N.S., Conneally, P.M., Naylor, S.L., Anderson, M.A., Tanzi, R.E., Witkins, P.C., Ottina, K., Wallance, M.R., Sakaguchi, A.Y., Young, A.B., Shoulson, I., Bonilla, E. and Mortin, J.B. 1983. A polymorphic DNA marker genetically linked to Huntington's disease.Nature 306: 234–238.
Kojima, T., Tanimoto, M., Kamiya, T., Obata, Y., Takahashi, T., Ohno, R., Kurachi, K. and Saito, H. 1987. Possible absence of common polymorphisms in coagulation factor IX gene in Japanese subjects.Blood 69: 349–352.
Mandel, J.L., Arveiler, B., Camerino, G., Hanauer, A., Heilig, R., Koenig, M. and Oberle, I. 1986. Genetic mapping of human X chromosome: linkage analysis of the q26–q28 region that includes the fragile X locus and isolation of expressed sequences.Cold Spring Harbor Sym. 51: 195–203.
Migeon, B.R., Moser, H.W., Moser, A.B., Axelman, J., Sillence, D. and Norum, R.A. 1981. Adrenoleukodystrophy: Evidence for X linkage, inactivation, and selection favoring the mutant allele in heterozygous cells.Proc. Natl. Acad. Sci. U.S.A. 78: 5066–5070.
Oberle, I., Drayna, D., Camerino, G., White, R. and Mandel, J.L. 1985. The telomeric region of the human X chromosome long arm: Presence of a highly polymorphic DNA marker and analysis of recombination frequency.Proc. Natl. Acad. Sci. U.S.A. 82: 2824–2828.
Paul, H., Galton, D. and Stocks, J. 1987. DNA polymorphic patterns and haplotype arrangements of the apoA-I, apoC-III, apoA-IV gene cluster in different ethnic groups.Hum. Genet. 75: 264–268.
Southern, E.M. 1975. Detection of specific sequence among DNA fragments separated by gel electrophoresis.J. Mol. Biol. 78: 503–517.
Suzuki, N., Nagao, T., and Nakahori, Y. 1988. Carrier detection of Hemophilia A in the Japanese population by use of four intragenic and extragenic RFLPs.Jpn. J. Clin. Hematol. 29: 19–26.
Tsui, L.-C., Buchwald, M., Barker, D., Braman, J.C., Knowlton, R., Schumm, J.W., Eiberg, H., Mohr, J., Kennedy, D., Plavsic, N., Zsiga, M., Markiewicz, D., Akots, G., Brown, D., Helms, C., Gravius, T., Parker, C., Rediker, K. and Donis-Keller, H. 1985. Cystic fibrosis locus defined by a genetically linked polymorphic DNA marker.Science 230: 1054–1057.
Wainscoat, J.S., Hill, A.V.S., Boyce, A.L., Flint, J., Hernandes, M., Thein, S.L., Old, J.M., Lynch, J.R., Falusi, A.G., Weatherall, D.J. and Clegg, J.B. 1986. Evolutionary relationships of human populations from an analysis of nuclear DNA polymorphisms.Nature 319: 491–493.
Wion, K.L., Tuddenham, E.D.G. and Lawn, R.M. 1986. A new polymorphism in the factor VIII gene for prenatal diagnosis of hemophilia A.Nucleic Acids Res. 14: 4535–4542.
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Taga, T., Shirahase, W., Shimada, M. et al. Restriction fragment length polymorphisms on the q24–q28 region of X chromosome among Japanese population. Jap J Human Genet 34, 123–128 (1989). https://doi.org/10.1007/BF01912480
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DOI: https://doi.org/10.1007/BF01912480
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