Summary
Genetic polymorphisms of the complement components C6 and C7 were investigated in Korean living in Seoul using isoelectric focusing and immunoblotting. Three common and four rare C6 allotypes were observed. The allele frequencies estimated were as follows:C6* A 0.433,C6* B 0.523,C6* B2 0.039, and rare alleles (M91, M92, M11 and M2) 0.005. Three C7 variants, besides a common allele, were observed with polymorphic frequencies. Two rare C7 variants, considered to be new, were also observed. The allele frequencies estimated forC7*1,C7*2,C7*3,C7*4, and rare variants (tentatively named K1 and K2) were 0.843, 0.073, 0.034, 0.048 and 0.002, respectively. The C6 and C7 allele frequencies are similar to those in Japanese and Chinese. The association analysis between C6 and C7 showed a significant negative association between C6 B and C7 4 allotypes (p<0.02).
Similar content being viewed by others
Article PDF
References
Hobart, M.J., Lachmann, P.J., and Alper, C.A. 1975. Polymorphism of human C6. InProtides of the Biological Fluids, 22nd Colloquim Brugge 1974, Peeters, H., ed., Pergamon Press, Oxford, pp. 575–580.
Hobart, M.J. and Lachmann, P.J. 1976. Allotypes of complement components in man.Transplant. Rev. 32:26–42.
Hobart, M.J., Joysey, V., and Lachmann, P.J. 1978. Inherited structural variation and linkage relationships of C7.J. Immunogenet. 5:157–163.
Kühnl, P. and Kreckel, P. 1980. C6 phenotypes and allele frequencies in a German population.Immunobiology 158:50–54.
Kunstmann, G., Mauff, G., and Pulverer, G. 1980. C6 polymorphism and rare alleles in Western Germany.Immunobiology 158:55–59.
Mauff, G., Alper, C.A., Hobart, M.J., Kühnl, P., Kunstmann, G., Meo, T., Olving, J.H., and Rittner, C. 1980. Statement on the nomenclature of human C6 polymorphism.Immunobiology 158:139–143.
Nakamura, S., Ooue, O., and Abe, K. 1984a. Genetic polymorphism of the seventh component of complement in a Japanese population.Hum. Genet. 66:279–281.
Nakamura, S., Ooue, O., Akiyama, K., and Abe, K. 1984b. Genetic polymorphism of complement C6 and haplotype analysis between C6 and C7 in a Japanese population.Hum. Genet. 68: 138–141.
Nishimukai, H., Kitamura, H., and Tamaki, Y. 1985. C6 polymorphism in Japanese: typing by agarose gel isoelectric focusing-immunofixation.Hum. Hered. 35:30–33.
Nishimukai, H. and Tamaki, Y. 1986. Genetic polymorphisms of the seventh component of complement: a new variant.Vox Sang. 51:60–62.
Park, K.S., Tokunaga, K., and Omoto, K. 1985. Genetic polymorphism of human complement components BF and C2 in Korean: Population and association studies.Jpn. J. Human Genet. 30:9–14.
Tokunaga, K., Yukiyama, Y., and Omoto, K. 1983. Polymorphism of the complement component C6 in Japanese.J. Immunogenet. 10:419–424.
Tokunaga, K., Yamamura, N., and Omoto, K. 1984. An immunoblotting technique for complement C6 typing: three new variants.Jpn. J. Human Genet. 29:415–419.
Tokunaga, K., Dewald, G., Omoto, K., and Juji, T. 1986. Family study on the polymorphisms of the sixth and seventh components (C6 and C7) of human complement: Linkage and haplotype analyses.Am. J. Hum. Genet. 39:414–419.
Washio, K., Tokunaga, K., Omoto, K., and Misawa, S. 1986. Human C7 polymorphism: classification and association analysis with C6.Jpn. J. Human Genet. 31:345–352.
Zeng, Z., Tokunaga, K., Omoto, K., and Du, C. 1986. Genetic polymorphisms of complement C6 and C7 in two Chinese populations.Jpn. J. Human Genet. 31:263–271.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Park, K.S., Yanagisawa, M., Tokunaga, K. et al. Genetic polymorphisms of complement components C6 and C7 in Korean. Jap J Human Genet 33, 325–331 (1988). https://doi.org/10.1007/BF02032862
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02032862
Keywords
This article is cited by
-
On the classification of C6 (tuberculum sextum) of the mandibular molars
Human Evolution (1994)