Summary
The genetic polymorphism of serum group-specific component (Gc) was studied in two Chinese (Han) populations using isoelectric focusing followed by immunofixation. Six common and seven rare variant phenotypes were observed among 155 samples from Beijing and 256 samples from Guangzhou. The frequencies for the common alleles,Gc * 1F,Gc * 1S, andGc * 2, were 0.4774, 0.2000, and 0.3065, respectively, for Beijing, and 0.4316, 0.2891, and 0.2734, respectively, for Guangzhou. Only the frequency ofGc * 1S showed a statistically significant difference between the two localities. The rare Gc variants observed were: Gc 1A3, Gc 1A8, Gc 1C18 and Gc 2A4. Furthermore, two new rare Gc variants were detected and named Gc 1C50 and Gc 2A19.
Similar content being viewed by others
Article PDF
References
Cleve, H., Constans, J., Berg, S., Hoste, B., Ishimoto, G., Matsumoto, H., Spees, E.K., and Weber, W. 1981. Gc revisited: Six further Gc-phenotypes delineated by isoelectric focusing and by polyacrylamide gel electrophoresis.Hum. Genet. 57:312–316.
Constans, J. and Viau, M. 1977. Group-specific component: Evidence for two subtypes of the Gc1 gene.Science 198:1070–1071.
Constans, J., Viau, M., Cleve, H., Jaeger, G., Quilici, J.C., and Palisson, M.J. 1978. Analysis of the Gc polymorphism in human population on polyacrylamide gels. Demonstration of subtypes of the Gc1 allele and of additional variants.Hum. Genet. 41:53–60.
Constans, J. and Cleve, H. 1979. Group-specific component. Report on the first international workshop.Hum. Genet. 48: 143–149.
Constans, J., Cleve, H., Dykes, D., Fischer, M., Kirk, R.L., Papiha, S.S., Scheffran, W., Scherz, R., Thymann, M., and Weber, W. 1983. Isoelectric focusing in 3m urea as additional method for identification of genetic variants.Hum. Genet. 65:176–180.
Ishimoto, G., Kuwata, M., and Nakajima, H., 1979. Group-specific component (Gc) polymorphism in Japanese: An analysis by isoelectric focusing on polyacrylamide gels.Jpn. J. Human Gent. 24:75–83.
Kamboh, M.I., Ranford, P.R. and Kirk, R.L. 1984. Population genetics of the vitamin D binding protein (Gc) subtypes in the Asian-Pacific area: Description of new alleles at the Gc locus.Hum. Genet. 67:378–384.
Kamboh, M.I., and Ferrell, R.E. 1986. Ethnic variation in vitamin D-binding protein (Gc): a review of isoelectric focusing studies in human populations.Hum. Genet. 72:281–293.
Kim, Y., Kwoky, Y., and Lewis, W.H.P. 1981. Group-specific component (Gc) subtypes in the Chinese population of Hongkong.Hum. Genet. 59:72–74.
Matsumoto, H., Matsui, K., Ishida, N., Ohkura, K., and Teng, Y.S. 1980. The distribution of Gc subtypes among the Mongoloid populations.Am. J. Phys. Anthropol. 53:505–508.
Nakasono, I., Iwasaki, M., Ogata, M., Yoshitake, T., Narita, K., Kubo, S., Suyama, H., and Tanoue, Y. 1985. A new hereditary single band variant of the Gc system.Hum. Genet. 70 84–85.
Omoto, K. and Miyake, K. 1978. The distribution of the group-specific component (Gc) subtypes in Japanese.Jpn. J. Human Genet. 23:119–125.
Omoto, K. 1986. The distribution of rell cell enzyme and serum protein types in a sample from Iwate, Northern Japan, with the description of geographical cline of Gc subtypes.J. Anthropol. Soc. Nippon 94:51–63.
Shibata, K. 1983. Haptoglobin, group-specific component, transferrin andα 1-antitrypsin subtypes and new variants in Japanese.Jpn. J. Human Genet. 28:17–27.
Tan, S.G., Gan, Y.Y., Asuan, K., and Abdullah, F. 1981. Gc subtyping in Malaysians and in Indonesians from North Sumatra.Hum. Genet. 59:75–76.
Yuasa, I., Saneshige, Y., and Okada, K. 1983. Geographical cline of allele frequency of groupspecific component (Gc) in the Japanese populations: An analysis of data obtained by immunoelectrophoresis.Jpn. J. Human Genet. 28: 255–261.
Yuasa, I., Suenaga, K., Gotoh, Y., Ito, K. and Yokoyama, N. 1984. Gc types in Western Japan: Report of a new variant Gc 1C35.Hum. Hered. 34:174–177.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zeng, Zm., Omoto, K. Group-specific component (Gc) subtypes in two chinese populations. Jap J Human Genet 32, 83–89 (1987). https://doi.org/10.1007/BF01893161
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01893161