Summary
This study was performed to investigate whether the ɛ4 allele of the apolipoprotein (apo) E predisposes Japanese male adults in large cities to hyperlipidemia. The apo E phenotypes and serum total lipid levels were determined using blood samples obtained after an overnight fast from 85 apparently healthy Japanese male civil servants in Tokyo. The frequency of hyperlipidemia was 50.0% in 20 subjects with the apo E4-positive phenotype and 25.8% in 62 subjects with the apo E3/3 phenotype. The difference is statistically significant (p<0.05). The mean (±SD) serum triglyceride levels, which were calculated on the subjects with serum triglyceride lower than 250 mg/dl, was 132.8±5.1 mg/dl in 18 subjects with the apo E4-positive phenotype and 108.4±43.0 mg/dl in 58 subjects with the apo E3/3 phenotype. The difference is also statistically significant (p<0.05). The data suggest that the ɛ4 allele might predispose Japanese adults in large cities to hyperlipidemia.
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Tsuchiya, S., Yamanouchi, Y., Miyazaki, R. et al. Apolipoprotein e phenotypes and serum lipid levels in apparently healthy male adults in Tokyo. Jap J Human Genet 31, 15–20 (1986). https://doi.org/10.1007/BF01876797
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DOI: https://doi.org/10.1007/BF01876797
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The Japanese Journal of Human Genetics (1987)