Summary
Genetic polymorphism of human plasminogen in Japanese was investigated in 373 plasma samples from blood donors using polyacrylamide gel isoelectric focusing followed by immunofixation. It was confirmed that two alleles which had not been described in Caucasoid and Negroid populations exist in Japanese. The correspondence of the alleles thus far described also was examined by comparison runs. As a result, it was revealed thatPLG 2′ described by Nakamuraet al. (1980a) is identical withPLG 2 described by Nishimukaiet al. (1981) and thatPLG C reported as a rare variant by Nishimukaiet al. (1982) corresponds toPLG 2 described by Hobart (1979). Allele frequencies were estimated as follows:PLGN *1=0.958,PLGN *2=0.004,PLGN *3=0.023,PLGN *4=0.015.
Caseinolytic activities per milligram antigen protein of different phenotypes were measured, and that of type 1–3 was about half of others. Therefore, the products ofPLGN *3 seem to have no or much lower activity than those of other alleles.
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Nishigaki, T., Omoto, K. Genetic polymorphism of human plasminogen in Japanese: Correspondence of alleles thus far reported in Japanese and difference of activity among phenotypes. Jap J Human Genet 27, 341–348 (1982). https://doi.org/10.1007/BF01900446
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DOI: https://doi.org/10.1007/BF01900446
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