Abstract
In the course of our screening program for regulators of circadian clock system (circadian rhythms), we isolated a new natural compound JBIR-26 (1) from Streptomyces sp. AK-AH76. The structure was determined to be 2-hydroxy-3,6-dimethylbenzoic acid on the basis of spectroscopic data. Compound 1 lengthened the periodlength of mammalian clocks for 1.5 hours at a concentration of 10 μg/ml.
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Izumikawa, M., Ukai, H., Takagi, M. et al. JBIR-26, a Novel Natural Compound from Streptomyces sp. AK-AH76, Regulates Mammalian Circadian Clock. J Antibiot 61, 756–758 (2008). https://doi.org/10.1038/ja.2008.90
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DOI: https://doi.org/10.1038/ja.2008.90