Abstract
From a study on the biological activity of fungal stemphones and their derivatives, five derivatives having an O-alkyl moiety at C-11 of stemphone C were found to inhibit lipid droplet accumulation in macrophages without any cytotoxic effect. Among the derivatives, those having O-isopropyl and O-isobutyl were the most potent inhibitors by blocking the synthesis of both cholesteryl ester (CE) and triacylglycerol (TG), the main constituents of lipid droplets in macrophages.
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Koyama, N., Kobayashi, K., Yamazaki, H. et al. Inhibition of Lipid Droplet Accumulation in Mouse Macrophages by Stemphone Derivatives. J Antibiot 61, 509–514 (2008). https://doi.org/10.1038/ja.2008.68
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DOI: https://doi.org/10.1038/ja.2008.68