Abstract
18-Amino-4″-O-benzoyl-4″′-N-demethyl-18-deoxospiramycins were designed and synthesized. Synthetic strategy involved selective demethylation of the dimethylamino group in forosamine, benzoylation of the hydroxyl group at the C4″ position and reductive N-amination of the formyl group. Antibacterial characteristics of spiramycin derivatives were tested. The derivatives exhibited promising activity against drug-resistant bacterial strains.
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Sunazuka, T., Shudo, H., Nagai, K. et al. 4″′-N-Demethylspiramycin Derivatives: Synthesis and Evaluation of Effectiveness against Drug-resistant Bacteria. J Antibiot 61, 175–184 (2008). https://doi.org/10.1038/ja.2008.127
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DOI: https://doi.org/10.1038/ja.2008.127