Abstract
Colletoic acid, a novel 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor, was found and isolated from the cultured broth of the producing fungus Colletotrichum gloeosporioides SANK 21404. Its structure was determined to be a novel acorene-type sesquiterpene by several spectroscopic methods. The absolute structure of colletoic acid was established using a modified Mosher's method and single-crystal X-ray diffraction analysis.
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Aoyagi, A., Ito-Kobayashi, M., Ono, Y. et al. Colletoic Acid, a Novel 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor from Colletotrichum gloeosporioides SANK 21404. J Antibiot 61, 136–141 (2008). https://doi.org/10.1038/ja.2008.122
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DOI: https://doi.org/10.1038/ja.2008.122