Abstract
In the course of our screening program for new inhibitors of IGF-I signaling, we isolated a new cytotoxic antibiotic, burkholone, from the culture broth of Burkholderia sp. QN15488. The structure of burkholone was determined to be (E)-3-methyl-2-(2-octenyl)-4-quinolone by a series of NMR analyses. Burkholone induced cell death 32D/GR15 cells with an IC50 value of 160 nM in IGF-I containing medium, while no cell death was observed in IL-3 containing medium even at the concentration of 37 μM.
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Mori, T., Yamashita, T., Furihata, K. et al. Burkholone, A New Cytotoxic Antibiotic against IGF-I Dependent Cells from Burkholderia sp.. J Antibiot 60, 713–716 (2007). https://doi.org/10.1038/ja.2007.92
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DOI: https://doi.org/10.1038/ja.2007.92
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