Abstract
A new indole-diterpene, JBIR-03 (1), was isolated from the fungus Dichotomomyces cejpii var. cejpii NBRC 103559 and its structure was determined based on the spectroscopic data. 1 exhibited anti-MRSA (methicillin-resistant Staphylococcus aureus) activity and antifungal activity against apple Valsa canker-causing fungus, Valsa ceratosperma, while it exhibited no toxicity towards human cancer cells.
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Livermore DM . β-Lactamases in laboratory and clinical resistance. Clin Microbiol Rev 8: 557–584 ( 1995)
Centers for Disease Control and Prevention . Staphylococcus aureus resistant to vancomycin-United States, 2002. Morb Mortal Wkly Rep 51: 565–567 ( 2002)
Sakuma T . Valsa canker. In Compendium of Apple and Pear Diseases. Ed., A. L. Jones, H. S. Aldwinckle, pp. 39–40, APS Press, St. Paul ( 1990)
Abe K, Kotoda N, Kato H, Soejima J . Resistance sources to Valsa canker (Valsa ceratosperma) in a germplasm collection of diverse Malus species. Plant Breeding 4: 449–453 ( 2007)
Nozawa K, Yuyama M, Nakajima S, Kawai K, Udagawa S . Studies on fungal products. part 19. Isolation and structure of a novel indoloditerpene, emindole SA, from Emericella striata. J Chem Soc, Perkin Trans 1: 2155–2160 ( 1988)
Fehr T, Acklin W . Die Ioslierung zweier neuartiger Indol-Derivate aus dem Mycel von Claviceps paspali Stevens et Hall. Helv Chim Acta 49: 1907–1910 ( 1966)
Ooike M, Nozawa K, Udagawa S, Kawai K . Structures of a new type of indoloditerpene, petromindole, and a new asterriquinone derivative, PM-53, from the ascostromata of Petromyces muricatus. Chem Pharm Bull 45: 1694–1696 ( 1997)
Springer JP, Clardy J, Wells JM, Cole RJ, Kirksey JW . The structure of paxilline, a tremorgenic metabolite of Penicillium paxilli Bainier. Tetrahedron Lett 16: 2531–2534 ( 1975)
Singh SB, Ondeyka JG, Jayasuriya H, Zink DL, Ha SN, Dahl-Roshak A, Greene J, Kim JA, Smith MM, Shoop W, Tkacz JS . Nodulisporic acids D∼F: Structure, biological activities, and biogenetic relationships. J Nat Prod 67: 1496–1506 ( 2004)
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Ogata, M., Ueda, Jy., Hoshi, M. et al. A Novel Indole-diterpenoid, JBIR-03 with Anti-MRSA Activity from Dichotomomyces cejpii var. cejpii NBRC 103559. J Antibiot 60, 645–648 (2007). https://doi.org/10.1038/ja.2007.83
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DOI: https://doi.org/10.1038/ja.2007.83
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