Abstract
A new member of the piericidin family, JBIR-02, was isolated from mycelium of Streptomyces sp. ML55 together with two known piericidin derivatives, piericidin A1 and IT-143-B. The structure was determined on the basis of spectroscopic data. JBIR-02 inhibited nuclear export of β-arrestin in HeLa cells at the concentration of 20 μM.
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Ueda, Jy., Togashi, T., Matukura, S. et al. A Novel Nuclear Export Inhibitor JBIR-02, a New Piericidin Discovered from Streptomyces sp. ML55. J Antibiot 60, 459–462 (2007). https://doi.org/10.1038/ja.2007.59
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DOI: https://doi.org/10.1038/ja.2007.59
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