Abstract
Two new cyclic lipopeptides, fusaristatins A (1) and B (2) were isolated from rice cultures of a Fusarium sp. YG-45 in the course of a screening of endophytic fungi. Their structures of 1 and 2 were determined by spectroscopic methods. 2 showed a moderate inhibitory effect on topoisomerases I (IC50: 73 μM) and II (IC50: 98 μM) without cleavable complexes. Furthermore, 1 and 2 showed the growth-inhibitory activity toward lung cancer cells LU 65 with IC50 values of 23 and 7 μM, respectively.
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Shiono, Y., Tsuchinari, M., Shimanuki, K. et al. Fusaristatins A and B, Two New Cyclic Lipopeptides from an Endophytic Fusarium sp.. J Antibiot 60, 309–316 (2007). https://doi.org/10.1038/ja.2007.39
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DOI: https://doi.org/10.1038/ja.2007.39
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