Abstract
Deficiency of Fas-mediated apoptosis is one of the mechanisms involved in the immune evasion by tumors. Thus, it might be a practical approach for cancer treatment that Fas-mediated apoptosis in tumor cells is modified by drugs. In the course of screening, we have isolated two new naphthoquinones, f13102A and B, from the culture broth of fungus strain F-13102. Coumpound f13102A sensitizes Fas-resistant human lung adenocarcinoma A549 cells to apoptosis.
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Yoshimoto, Y., Kawada, M., Kumagai, H. et al. New Naphthoquinones, f13102A and B, from a Fungus Strain F-13102. J Antibiot 58, 590–593 (2005). https://doi.org/10.1038/ja.2005.80
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DOI: https://doi.org/10.1038/ja.2005.80