Abstract
In our systematic screening programme for marine actinomycetes, a bioactive streptomycete was isolated from marine sediment samples of the Bay of Bengal, India. The isolate yielded a new cytotoxic compound. This was obtained by solvent extraction followed by chromatographic purification. The pure compound was identified from spectroscopic data as a quinone-related antibiotic, 1-hydroxy-1-norresistomycin (1). It showed a potent cytotoxic activity against cell lines viz. HMO2 (gastric adenocarcinoma) and HePG2 (hepatic carcinoma) in vitro. It also exhibited antibacterial activities against Gram-positive and Gram-negative bacteria.
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†The same compound (1-hydroxy-1-norresistomycin) which was isolated independently from different strains appears in this issue (pages 530-534).
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Gorajana, A., Kurada, B., Peela, S. et al. 1-Hydroxy-1-norresistomycin, a New Cytotoxic Compound from a Marine Actinomycete, Streptomyces chibaensis AUBN1/7 †. J Antibiot 58, 526–529 (2005). https://doi.org/10.1038/ja.2005.72
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DOI: https://doi.org/10.1038/ja.2005.72
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