Original Article

Morning and afternoon appetite and gut hormone responses to meal and stress challenges in obese individuals with and without binge eating disorder

  • International Journal of Obesity volume 42, pages 841849 (2018)
  • doi:10.1038/ijo.2017.307
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Received:
Revised:
Accepted:
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Subjects

Abstract

Background:

Eating late in the day is common, and stress can induce eating. Little is understood about how time of day and stress interact to affect appetite and thereby body weight. These may be particularly important influences in binge eaters, who tend to binge in the evening, and in response to stress.

Method:

Obese participants with (n=16) and without (n=16) binge eating disorder (BED) participated in two identical test protocols beginning either in the morning or the afternoon (AM condition/PM condition), each following an 8 h fast. For each protocol, they first received a standardized liquid meal (0900/1600 hours), then a stress test (Socially Evaluated Cold Pressor Test, 1110/1810 hours), and then a multi-item ad libitum buffet meal (1140/1840 hours) while rating appetite and stress and having blood drawn for hormone measures.

Results:

Appetite at baseline was greater in the PM than in the AM condition (higher hunger, lower fullness). Following the liquid meal, area under the curve (AUC) values for hunger and ghrelin were greater and AUC values for peptide YY lower in the PM than in the AM condition. Only those with BED showed lower fullness AUC in the PM condition, as well as a pattern of higher initial PM and lower initial AM ghrelin. Following the stress test, cortisol and ghrelin increased in both the AM and PM conditions, but higher ghrelin AUC and lower cortisol AUC were observed in the PM condition. Again, only participants with BED showed lower fullness AUC in the PM condition. Buffet meal intake was similar across groups and conditions but those with BED reported greater loss of control and binge resemblance than those without.

Conclusions:

Afternoon/evening may be a high-risk period for overeating, particularly when paired with stress exposure, and for those with binge eating.

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Acknowledgements

This work was conducted at the New York Obesity Nutrition Research Center at St Luke’s-Roosevelt Hospital and Columbia University College of Physicians and Surgeons, with the support of funding from NIDDK (R01DK074046, PI: AG; K99DK088360, PI: SC) and additional support for SC from NIH grants K99 R00DK088360 (PI: SC) and U54HD070725. We thank Kushi Ranganath for help in reviewing the literature.

Author information

Author notes

    • S Carnell
    •  & C Grillot

    S Carnell and C Grillot are joint first authors.

Affiliations

  1. Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA

    • S Carnell
  2. Department of Psychology, Florida State University, Tallahassee, FL, USA

    • C Grillot
  3. Mt Sinai St Luke’s Hospital, Icahn School of Medicine at Mt Sinai, New York, NY, USA

    • T Ungredda
    • , S Ellis
    • , N Mehta
    •  & A Geliebter
  4. Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

    • J Holst
  5. Department of Psychiatry, Icahn School of Medicine at Mt Sinai, New York, NY, USA

    • A Geliebter
  6. Department of Psychology, Touro College and University System, New York, NY, USA

    • A Geliebter

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Competing interests

The authors declare no conflict of interest.

Corresponding author

Correspondence to S Carnell.

Supplementary information

Supplementary Information accompanies this paper on International Journal of Obesity website (http://www.nature.com/ijo)