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Clinical Studies and Practice

Abdominal fat deposits determined by magnetic resonance imaging in relation to leptin and vaspin levels as well as insulin resistance in the general adult population

International Journal of Obesity volume 42, pages 183–189 (2018)Cite this article

Subjects

Abstract

Background:

Various fat depots including visceral (VAT), subcutaneous adipose tissue (SAT) or liver fat content (LFC) were supposed to have different influences on various entities including adipokine levels as well as insulin resistance/sensitivity. Therefore, the aim of the study was to investigate the associations of SAT, VAT and LFC with the levels of leptin and vaspin as well as insulin resistance in a general non-diabetic population.

Methods:

In total, 1825 participants of the Study of Health in Pomerania were characterized according to body fat compartments and LFC determined by magnetic resonance imaging. Of those subjects, insulin resistance (HOMA-IR) and insulin sensitivity ([ISI(comp)) were determined in 981 participants and adipokines were assessed in 698 using enzyme-linked immunosorbent assay. Analyses of variance and linear regression models adjusted for age, sex, smoking, height, physical inactivity and alcohol consumption were used for analysis.

Results:

Using the residual method to assess independently the effect of the various fat depots, a strong positive association of SAT (beta per standard deviation (s.d.) increase 0.54 (95% confidence interval (CI) 0.47–0.60)) but not VAT (beta 0.01 (95% CI −0.08 to 0.09)) and LFC (beta 0.01 (95% CI −0.06 to 0.08)) with log2-leptin levels was found independent of the HOMA-IR status. Moreover, a positive association of LFC (beta 0.17 (95% CI 0.07–0.26)) with log2-vaspin levels becomes apparent, which were mostly driven by subjects with a low HOMA-IR. With respect to HOMA-IR and ISI(comp) index, pronounced positive and inverse associations to all fat markers were revealed, respectively, with the strongest relation found for SAT and LFC.

Conclusions:

SAT and LFC were identified as predominant sites associated with leptin and vaspin levels, respectively. Residual analysis pointed towards a general adverse effect of disproportional triglyceride storage across physiological despots, in particular in ectopic sides such as the liver, with markers of insulin resistance.

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Acknowledgements

This work was funded by grants from the German Federal Ministry of Education and Research (BMBF, Grants 01ZZ0403, 01ZZ0103, 01GI0883), the Ministry for Education, Research and Cultural Affairs as well as the Ministry of Social Affairs of the Federal State of Mecklenburg-West Pomerania. This work is also part of the research project Greifswald Approach to Individualized Medicine (GANI_MED). The GANI_MED consortium is funded by the Federal Ministry of Education and Research and the Ministry of Cultural Affairs of the Federal State of Mecklenburg-West Pomerania (03IS2061A).

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Authors and Affiliations

  1. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, , Greifswald, Germany

    F Genske, M Pietzner, H Wallaschofski & N Friedrich

  2. Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, , Greifswald, Germany

    J-P Kühn

  3. Department of Diagnostic Radiology, University Hospital, Carl Gustav Carus University, Dresden, Germany

    J-P Kühn

  4. DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany

    M Pietzner & N Friedrich

  5. Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany

    G Homuth

  6. Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany

    W Rathmann

  7. Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany

    H J Grabe

  8. Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

    H Völzke

  9. Schwerpunktpraxis für Diabetes und Hormonerkrankungen, Erfurt, Germany

    H Wallaschofski

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Genske, F., Kühn, JP., Pietzner, M. et al. Abdominal fat deposits determined by magnetic resonance imaging in relation to leptin and vaspin levels as well as insulin resistance in the general adult population. Int J Obes 42, 183–189 (2018). https://doi.org/10.1038/ijo.2017.187

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