Abstract
Background/Objectives:
Fabuless (Olibra) is a commercially structured lipid emulsion, claimed to be a food ingredient that is effective for food intake and appetite reduction. The present study assessed its efficacy in a yoghurt-based mini-drink undergoing low or minimal food manufacturing (thermal and shear) processes.
Subjects/Methods:
Study 1: Twenty-four healthy volunteers (16 female, 8 male; age: 18–47 years; body mass index (BMI): 17–28 kg m−2) took part in a randomised, placebo-controlled, double-blind parallel crossover trial. Consumption of a minimally processed ‘preload’ mini-drink (containing two different doses of Fabuless or a control fat) at 2 h after breakfast was followed by appetite and mood ratings, and food intake measured in ad libitum meals at 3 and 7 h post consumption of the preload. Study 2: As Study 1 (16 female, 8 male; age: 20–54 years; BMI: 21–30 kg m−2). A chilled, virtually unprocessed, preload breakfast mini-drink (containing minimally processed Fabuless or a control fat) was provided 5 min after a standardised breakfast, followed by appetite and mood ratings, and food intake measured in ad libitum meals at 4 and 8 h post consumption of the preload.
Results:
The structured lipid emulsion tested had no significant effect on the primary measures of food intake or appetite.
Conclusions:
Even when exposed to minimal food-manufacturing conditions, Fabuless showed no efficacy on measures of appetite and food intake.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Delgado-Aros S, Kim D-Y, Burton DD, Thomforde GM, Stephens D, Brinkmann BH et al. Effect of GLP-1 on gastric volume, emptying, maximum volume ingested, and postprandial symptoms in humans. Am J Physiol 2002; 282: G424–G431.
Brubaker PL, Drucker DJ, Asa SL, Swallow C, Redston M, Greenberg GR . Prolonged gastrointestinal transit in a patient with a glucagon-like peptide (GLP)-1- and -2-producing neuroendocrine tumor. J Clin Endocrinol Metab 2002; 87: 3078–3083.
Giralt M, Vergara P . Glucagonlike peptide-1 (GLP-1) participation in ileal brake induced by intraluminal peptones in rat. Dig Dis Sci 1999; 44: 322–329.
Näslund E, Bogefors J, Skogar S, Grybäck P, Jacobsson H, Holst JJ et al. GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans. Am J Physiol 1999; 277: R910–R916.
Maljaars PWJ, Peters HPF, Mela DJ, Masclee AAM . Ileal brake: a sensible food target for appetite control. A review. Physiol Behav 2008; 95: 271–281.
Knutson L, Koenders DJ, Fridblom H, Viberg A, Sein A, Lennernäs H . Gastrointestinal metabolism of a vegetable-oil emulsion in healthy subjects. Am J Clin Nutr 2010; 92: 515–524.
Fabuless – Map. http://www.dsm.com/le/en_US/fabuless/html/map.htm (accessed 2 September 2011).
Appleton KM, Smit HJ, Rogers PJ . Review and meta-analysis of the short-term effects of a vegetable oil emulsion on food intake. Obes Rev 2011; 12: e560–e572.
Burns AA, Livingstone MBE, Welch RW, Dunne A, Robson PJ, Lindmark L et al. Short-term effects of yoghurt containing a novel fat emulsion on energy and macronutrient intakes in non-obese subjects. Int J Obes 2000; 24: 1419–1425.
Burns AA, Livingstone MBE, Welch RW, Dunne A, Reid CA, Rowland IR . The effects of yoghurt containing a novel fat emulsion on energy and macronutrient intakes in non-overweight, overweight and obese subjects. Int J Obes 2001; 25: 1487–1496.
Burns AA, Livingstone MBE, Welch RW, Dunne A, Rowland IR . Dose-response effects of a novel fat emulsion (Olibra™) on energy and macronutrient intakes up to 36 h post-consumption. Eur J ClinNutr 2002; 56: 368–377.
Diepvens K, Steijns J, Zuurendonk P, Westerterp-Plantinga MS . Short-term effects of a novel fat emulsion on appetite and food intake. Physiol Behav 2008; 95: 114–117.
Smit HJ, Keenan E, Kovacs EMR, Wiseman SA, Peters HPF, Mela DJ et al. No efficacy of processed Fabuless (Olibra) in suppressing appetite or food intake. Eur J Clin Nutr 2011; 65: 81–86.
Chan Y-K, Strik CM, Budgett S, McGill A-T, Proctor J, Poppitt SD . The emulsified lipid Fabuless (Olibra) does not decrease food intake but suppresses appetite when consumed with yoghurt but not alone or with solid foods: a food effect study. Physiol Behav 2011; 105: 742–748.
Logan CM, McCaffrey TA, Wallace JMW, Robson PJ, Welch RW, Dunne A et al. Investigation of the medium-term effects of Olibra™ fat emulsion on food intake in non-obese subjects. Eur J Clin Nutr 2006; 60: 1081–1091.
Van Strien T, Frijters JER, Bergers GPA, Defares PB . The Dutch eating behaviour questionnaire for assessment of restrained, emotional and external eating behaviour. Int J Eat Disord 1986; 5: 295–315.
Van Strien T, Frijters JER, Bergers GPA, Defares PB (eds). Nederlandse Vragenlijst voor Eetgedrag (NVE), handleiding, [Dutch Eating Behavior Questionnaire (DEBQ), manual]. Swets&Zeitlinger b.v.: Lisse, The Netherlands, 1986.
Davies J, Dickerson J . Nutrient Content of Food Portions. The Royal Society of Chemistry: Cambridge, UK, 1991.
Rogers PJ, Blundell JE . Effect of anorexic drugs on food intake and the micro-structure of eating in human subjects. Psychopharmacology (Berl.) 1979; 66: 159–165.
Rolls BJ, Shide DJ, Thorwart ML, Ulbrecht JS . Sibutramine reduces food intake in non-dieting women with obesity. Obes Res 1998; 6: 1–11.
Blundell J, de Graaf C, Hulshof T, Jebb S, Livingstone B, Lluch A et al. Appetite control: methodological aspects of the evaluation of foods. Obes Rev 2010; 11: 251–270.
McClements DJ (ed.). Food Emulsions: Principles, Practice and Techniques, 2nd edn. CRC Press: Boca Raton, USA, 2005.
Lin HC, Zhao X-T, Wang L . Fat absorption is not complete by midgut but is dependent on load of fat. Am J Physiol 1996; 271: G62–G67.
Feinle C, O’Donovan D, Doran S, Andrews JM, Wishart J, Chapman I et al. Effects of fat digestion on appetite, APD motility, and gut hormones in response to duodenal fat infusion in humans. Am J Physiol 2003; 284: G798–G807.
Näslund E, Grybäck P, Backman L, Jacobsson H, Holst JJ, Theodorsson E et al. Distal small bowel hormones: correlating with fasting antroduodenal motility and gastric emptying. Dig Dis Sci 1998; 43: 945–952.
Zhao X-T, Wang L, Lin HC . Slowing of intestinal transit by fat depends on naloxone-blockable efferent, opioid pathway. Am J Physiol 2000; 278: G866–G870.
Haenni A, Sundberg B, Yazdanpanah N, Viberg A, Olsson J . Effect of fat emulsion (Fabuless) on orocecal transit time in healthy men. Scand J Gastroenterol 2009; 44: 1186–1190.
Peters P, Beglinger C, Mela D, Schuring E . Comment and reply on: effect of emulsion (Fabuless) on orocecal transit time in healthy men. Scand J Gastroenterol 2010; 45: 637–638.
Acknowledgements
This work was funded by Unilever R&D, Vlaardingen, The Netherlands.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
Dr Smit, Professor Rogers and Mrs Keenan declare no conflict of interest. Dr Mela, Dr Wiseman and Dr Kovacs represent the funding company, which manufactures meal replacement products for weight control.
Rights and permissions
About this article
Cite this article
Smit, H., Keenan, E., Kovacs, E. et al. No appetite efficacy of a commercial structured lipid emulsion in minimally processed drinks. Int J Obes 36, 1222–1228 (2012). https://doi.org/10.1038/ijo.2011.237
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/ijo.2011.237
Keywords
This article is cited by
-
Effects of lipid emulsion particle size on satiety and energy intake: a randomised cross-over trial
European Journal of Clinical Nutrition (2018)