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Bariatric Surgery

Body composition changes after laparoscopic adjustable gastric banding: what is the role of −174G>C interleukin-6 promoter gene polymorphism in the therapeutic strategy?

International Journal of Obesity volume 36, pages 369–378 (2012)Cite this article

Abstract

Background:

There is growing evidence that interleukin-6 (IL-6) is linked to the regulation of fat mass (FM). Our previous data define the common −174G>C IL-6 polymorphism as a marker for ‘vulnerable’ individuals at risk of age- and obesity-related diseases. An association between −174G>C IL-6 polymorphism and weight loss after bariatric surgery has been demonstrated.

Objective:

We investigated the impact of −174G>C IL-6 polymorphism on weight loss, body composition, fluid distribution and cardiometabolic changes in obese subjects, after laparoscopic adjustable gastric banding (LAGB) surgery.

Design and Outcome measures:

A total of 40 obese subjects were studied at baseline and at 6 months follow-up after LAGB surgery. Cardiometabolic and genetic assessment of −174G>C IL-6 polymorphism, anthropometric, body composition and fluid distribution analysis were performed.

Results:

After LAGB surgery, significant reductions in weight (Δ%=−11.66±7.78, P<0.001), body mass index (P<0.001), total and trunk FM (kg, %) (Δ% of total FM=−22.22±12.15, P<0.01), bone mineral density (T-score) (P<0.001), resting metabolic rate (RMR) (P<0.01), and total body water and intracellular water (TBW, ICW) (P<0.05) were observed. At baseline, C(−) carriers of IL-6 polymorphism had a significantly higher RMR (P<0.05), free FM (kg), but less total and trunk FM (%), higher body cell mass (BCM), content of TBW (L) and ECW (extracellular water)/ICW ratio compared with C(+) carriers (P<0.001). After LAGB, C(+) carriers had a significantly stronger reduction of total FM (kg), but lower bone density, compared with C(−) carriers (P<0.05).

Conclusions:

Beyond the relationship between −174G>C IL-6 polymorphism and body composition, this study provides first evidence about the association of IL-6 variant with fluid distribution, at baseline, and FM and bone density loss in obese subjects at 6 months follow-up after LAGB surgery. LAGB was less effective if the subjects were carrying risk genotypes, C(−) carriers, for obesity, suggesting a role of genetic variations on bariatric surgery outcomes.

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Acknowledgements

This study was supported by grants from Ministero Politiche Agricole e Forestali, Italy (PACB, D.M. 91567 Dic 29, 2004/2008). We thank Federica Fabiocchi, Annamaria Di Dionisio and Gaia Giugno for their contribution to this study.

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Authors and Affiliations

  1. Department of Neuroscience, Division of Human Nutrition, University of Rome Tor Vergata, Rome, Italy

    L Di Renzo, A Bianchi, L Iacopino & A De Lorenzo

  2. I.N.Di.M., National Institute for Mediterranean Diet and Nutrigenomic, Reggio Calabria, Rome, Italy

    L Di Renzo & A De Lorenzo

  3. Azienda Ospedaliera San Camillo-Forlanini, Rome, Italy

    M G Carbonelli

  4. Department of Surgery, University of Tor Vergata, Rome, Italy

    R Fiorito

  5. Department of Internal Medicine, University of Tor Vergata, Rome, Italy

    N Di Daniele

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  1. L Di Renzo
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Correspondence to A De Lorenzo.

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Di Renzo, L., Carbonelli, M., Bianchi, A. et al. Body composition changes after laparoscopic adjustable gastric banding: what is the role of −174G>C interleukin-6 promoter gene polymorphism in the therapeutic strategy?. Int J Obes 36, 369–378 (2012). https://doi.org/10.1038/ijo.2011.132

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