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Acute, short-term hyperinsulinemia increases olfactory threshold in healthy subjects

International Journal of Obesity volume 35, pages 1135–1138 (2011)Cite this article

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Abstract

Objective:

Smell plays an important role in feeding behavior. We therefore tested whether insulin as a postprandial signal is involved in the regulation of olfactory function.

Research design and methods:

We assessed olfactory thresholds in eight lean subjects (age: 34±7 years, M/F: 5/3) before and during a 2-h hyperinsulinemic (1 mU kg−1 min−1) euglycemic clamp and in eight lean fasted subjects (age: 36±6 years, M/F: 5/3) without insulin infusion at the same time of the day. To define odor thresholds, standardized ‘sniffing sticks’ were used.

Results:

Odor thresholds decreased from 7.8±1.2 to 6.2±1.1 during euglycemic hyperinsulinemia (P=0.0173), representing an increase in odor threshold. In the control group, odor thresholds were 8.3±1.6 and did not change after 120 min of fasting (8.9±2.2, P=0.6).

Conclusions:

Increased insulin levels lead to a reduced smelling capacity, potentially reducing the pleasantness of eating. Therefore, insulin action in the olfactory bulb may be involved in the process of satiation and may thus be of interest in the pathogenesis of obesity.

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References

  1. Aschenbrenner K, Hummel C, Teszmer K, Krone F, Ishimaru T, Seo HS et al. The influence of olfactory loss on dietary behaviors. Laryngoscope 2008; 118: 135–144.

    Article  PubMed  Google Scholar 

  2. Aime P, Duchamp-Viret P, Chaput MA, Savigner A, Mahfouz M, Julliard AK . Fasting increases and satiation decreases olfactory detection for a neutral odor in rats. Behav Brain Res 2007; 179: 258–264.

    Article  CAS  PubMed  Google Scholar 

  3. Albrecht J, Schreder T, Kleemann AM, Schopf V, Kopietz R, Anzinger A et al. Olfactory detection thresholds and pleasantness of a food-related and a non-food odour in hunger and satiety. Rhinology 2009; 47: 160–165.

    CAS  PubMed  Google Scholar 

  4. Furchtgott E, Friedman MP . The effects of hunger on taste and odor RLs. J Comp Physiol Psychol 1960; 53: 576–581.

    Article  CAS  PubMed  Google Scholar 

  5. Koelega HS . Diurnal variations in olfactory sensitivity and the relationship to food intake. Percept Mot Skills 1994; 78: 215–226.

    Article  CAS  PubMed  Google Scholar 

  6. Baly C, Aioun J, Badonnel K, Lacroix MC, Durieux D, Schlegel C et al. Leptin and its receptors are present in the rat olfactory mucosa and modulated by the nutritional status. Brain Res 2007; 1129: 130–141.

    Article  CAS  Google Scholar 

  7. Hass N, Haub H, Stevens R, Breer H, Schwarzenbacher K . Expression of adiponectin receptor 1 in olfactory mucosa of mice. Cell Tissue Res 2008; 334: 187–197.

    Article  CAS  Google Scholar 

  8. Guthoff M, Tschritter O, Berg D, Liepelt I, Schulte C, Machicao F et al. Effect of genetic variation in Kv1.3 on olfactory function. Diabetes Metab Res Rev 2009; 25: 523–527.

    Article  CAS  Google Scholar 

  9. Hummel T, Sekinger B, Wolf SR, Pauli E, Kobal G . Sniffin’ sticks’: olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem Senses 1997; 22: 39–52.

    Article  CAS  Google Scholar 

  10. Stefan N, Machicao F, Staiger H, Machann J, Schick F, Tschritter O et al. Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. Diabetologia 2005; 48: 2282–2291.

    Article  CAS  Google Scholar 

  11. Le Floch JP, Le Lievre G, Labroue M, Paul M, Peynegre R, Perlemuter L . Smell dysfunction and related factors in diabetic patients. Diabetes Care 1993; 16: 934–937.

    Article  CAS  Google Scholar 

  12. Julliard AK, Chaput MA, Apelbaum A, Aime P, Mahfouz M, Duchamp-Viret P . Changes in rat olfactory detection performance induced by orexin and leptin mimicking fasting and satiation. Behav Brain Res 2007; 183: 123–129.

    Article  CAS  Google Scholar 

  13. Savigner A, Duchamp-Viret P, Grosmaitre X, Chaput M, Garcia S, Ma M et al. Modulation of spontaneous and odorant-evoked activity of rat olfactory sensory neurons by two anorectic peptides, insulin and leptin. J Neurophysiol 2009; 101: 2898–2906.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Marks DR, Tucker K, Cavallin MA, Mast TG, Fadool DA . Awake intranasal insulin delivery modifies protein complexes and alters memory, anxiety, and olfactory behaviors. J Neurosci 2009; 29: 6734–6751.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Hallschmid M, Benedict C, Born J, Fehm HL, Kern W . Manipulating central nervous mechanisms of food intake and body weight regulation by intranasal administration of neuropeptides in man. Physiol Behav 2004; 83: 55–64.

    Article  CAS  PubMed  Google Scholar 

  16. Richardson BE, Vander Woude EA, Sudan R, Thompson JS, Leopold DA . Altered olfactory acuity in the morbidly obese. Obes Surg 2004; 14: 967–969.

    Article  PubMed  Google Scholar 

  17. Roessner V, Bleich S, Banaschewski T, Rothenberger A . Olfactory deficits in anorexia nervosa. Eur Arch Psychiatry Clin Neurosci 2005; 255: 6–9.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

This study was supported by a grant of the Competence Network for Adipositas funded by the Federal Ministry of Education and Research (FKZ: 01GI0849) and a grant of the Zentrum Ernährungsmedizin Tübingen-Hohenheim (ZEM, grant number 2 A I).

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tübingen, Tübingen, Germany

    C Ketterer, M Heni, C Thamer, S A Herzberg-Schäfer, H-U Häring & A Fritsche

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  1. C Ketterer
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  2. M Heni
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  3. C Thamer
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  4. S A Herzberg-Schäfer
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Correspondence to A Fritsche.

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The authors declare no conflict of interest.

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Ketterer, C., Heni, M., Thamer, C. et al. Acute, short-term hyperinsulinemia increases olfactory threshold in healthy subjects. Int J Obes 35, 1135–1138 (2011). https://doi.org/10.1038/ijo.2010.251

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