Abstract
Objective:
The objective of this study was to analyze how fat partitioning in the liver, muscle and visceral compartments is altered by diabetes and age, and whether altered fat distribution is associated with a higher carotid artery intima-media thickness (C-IMT) and insulin resistance.
Methods:
This was an observational study performed on 21 young healthy men (mean age±s.d., 28.6±3.8 years) and 73 men with newly developed type 2 diabetes (38 young (29.2±4.1 years) and 35 middle-aged (47.1±6.0 years) subjects). Abdominal visceral and subcutaneous fat areas, mid-thigh muscle attenuation and liver attenuation characteristics were determined; the mid-thigh muscle was divided into low- and normal-density muscle areas.
Results:
The young and middle-aged diabetic subjects had higher visceral fat areas, higher liver attenuation and higher lipid-rich muscle (greater low-density muscle area and decreased muscle attenuation) when compared with healthy individuals; however, no differences were observed between the two diabetic groups. In contrast, the C-IMT increased with both age and diabetes. On the basis of multiple regression analyses, mid-thigh low-density muscle area and muscle attenuation were independently associated with the C-IMT, and the mid-thigh normal-density muscle area and muscle attenuation were independent factors of insulin resistance.
Conclusions:
High fat stores within ectopic compartments were observed at an early stage in the development of diabetes. Furthermore, altered lipid partitioning within muscle was independently associated with carotid atherosclerosis and insulin resistance.
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References
Stein J, Colditz GA . The epidemic of obesity. J Clin Endocrinol Metab 2004; 89: 2522–2525.
Larsson B, Svärdsudd K, Welin L, Wilhelmsen L, Björntorp P, Tibblin G . Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913. Br Med J (Clin Res Ed) 1984; 288: 1401–1404.
Després JP, Moorjani S, Lupien PJ, Tremblay A, Nadeau A, Bouchard C . Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease. Arteriosclerosis 1990; 10: 497–511.
Despres JP . Is visceral obesity the cause of the metabolic syndrome? Ann Med 2006; 38: 52–63.
Kelley DE, Goodpaster BH . Skeletal muscle triglyceride. An aspect of regional adiposity and insulin resistance. Diabetes Care 2001; 24: 933–941.
Korenblat KM, Fabbrini E, Mohammed BS, Klein S . Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. Gastroenterology 2008; 134: 1369–1375.
Koska J, Stefan N, Permana PA, Weyer C, Sonoda M, Bogardus C et al. Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoadiponectinemia in obese individuals. Am J Clin Nutr 2008; 87: 295–302.
Goodpaster BH, Thaete FL, Kelley DE . Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus. Am J Clin Nutr 2000; 71: 885–892.
Longo RRC, Masutti F, Vidimari R, Croce LS, Bercich L, Tiribelli C et al. Fatty infiltration of the liver. Quantification by 1 H localized magnetic resonance spectroscopy and comparison with computed tomography. Invest Radiol 1993; 28: 297–302.
Kelley DE, Slasky BS, Janosky J . Skeletal muscle density: effects of obesity and non-insulin-dependent diabetes mellitus. Am J Clin Nutr 1991; 54: 509–515.
Yanase T, Nasu S, Mukuta Y, Shimizu Y, Nishihara T, Okabe T et al. Evaluation of a new carotid intima-media thickness measurement by B-mode ultrasonography using an innovative measurement software, intimascope. Am J Hypertens 2006; 19: 1206–1212.
Despres JP, Lemieux I . Abdominal obesity and metabolic syndrome. Nature 2006; 444: 881–887.
Kim SK, Park SW, Kim SH, Cha BS, Lee HC, Cho YW . Visceral fat amount is associated with carotid atherosclerosis even in type 2 diabetic men with a normal waist circumference. Int J Obes (London) 2009; 33: 131–135.
Stefan N, Kantartzis K, Machann J, Schick F, Thamer C, Rittig K et al. Identification and characterization of metabolically benign obesity in humans. Arch Intern Med 2008; 168: 1609–1616.
Lapidus L, Bengtsson C, Larsson B, Pennert K, Rybo E, Sjöström L . Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden. Br Med J (Clin Res Ed) 1984; 289: 1257–1261.
Ducimetiere P, Richard J, Cambien F . The pattern of subcutaneous fat distribution in middle-aged men and the risk of coronary heart disease: the Paris Prospective Study. Int J Obes 1986; 10: 229–240.
Nicklas BJ, Penninx BW, Cesari M, Kritchevsky SB, Newman AB, Kanaya AM et al. Association of visceral adipose tissue with incident myocardial infarction in older men and women: the Health, Aging and Body Composition Study. Am J Epidemiol 2004; 160: 741–749.
Boyko EJ, Fujimoto WY, Leonetti DL, Newell-Morris L . Visceral adiposity and risk of type 2 diabetes: a prospective study among Japanese Americans. Diabetes Care 2000; 23: 465–471.
Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI . Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 2004; 350: 664–671.
Targher G, Bertolini L, Rodella S, Tessari R, Zenari L, Lippi G et al. Nonalcoholic fatty liver disease is independently associated with an increased incidence of cardiovascular events in type 2 diabetic patients. Diabetes Care 2007; 30: 2119–2121.
Targher G, Bertolini L, Padovani R, Rodella S, Zoppini G, Zenari L et al. Relations between carotid artery wall thickness and liver histology in subjects with nonalcoholic fatty liver disease. Diabetes Care 2006; 29: 1325–1330.
Taksali SE, Caprio S, Dziura J, Dufour S, Calí AM, Goodman TR et al. High visceral and low abdominal subcutaneous fat stores in the obese adolescent: a determinant of an adverse metabolic phenotype. Diabetes 2008; 57: 367–371.
Hwang IJ, Park KS, Chae YT, Shi KD, Kim SK, Park SW et al. Role of thigh muscle in the carotid artery intima-media thickness and insulin resistance. J Kor Soc Endocrinol 2005; 20: 452–459.
Boesch C, Slotboom J, Hoppeler H, Kreis R . In vivo determination of intra-myocellular lipids in human muscle by means of localized 1H-MR-spectroscopy. Magn Reson Med 1997; 37: 484–493.
Goodpaster BH, Kelley DE, Thaete FL, He J, Ross R . Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content. J Appl Physiol 2000; 89: 104–110.
Kelley DE, Williams KV, Price JC, McKolanis TM, Goodpaster BH, Thaete FL . Plasma fatty acids, adiposity, and variance of skeletal muscle insulin resistance in type 2 diabetes mellitus. J Clin Endocrinol Metab 2001; 86: 5412–5419.
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Kim, SK., Park, SW., Hwang, IJ. et al. High fat stores in ectopic compartments in men with newly diagnosed type 2 diabetes: an anthropometric determinant of carotid atherosclerosis and insulin resistance. Int J Obes 34, 105–110 (2010). https://doi.org/10.1038/ijo.2009.210
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DOI: https://doi.org/10.1038/ijo.2009.210
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