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  • Original Article
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Coadministration of Coenzyme Q prevents Rosiglitazone-induced adipogenesis in ob/ob mice

International Journal of Obesity volume 33, pages 204–211 (2009)Cite this article

Abstract

Objective:

The aim of this study is to determine the effect of coenzyme Q (Q) on ob/ob mice treated or not with thiazolidinedione (TZD).

Design and measurements:

Ob/ob mice were treated with Q, Rosiglitazone or a combination of both molecules for 13 days; physical and metabolic parameters as well as oral glucose tolerance test were assessed. mRNA expression of genes of energy dissipation and storage were measured by real-time PCR.

Results:

Q treatment improved some metabolic parameters in ob/ob mice. Surprisingly, cotreatment with Rosiglitazone and Q improved metabolic parameters and prevented TZD increase in body weight and adiposity, mainly by increasing lipid oxidation in adipose tissue, reducing lipid synthesis and balancing adipokine gene expression.

Conclusions:

Our finding suggests that Rosiglitazone and coenzyme Q bitherapy could prevent the body weight gain associated with adipogenesis and could improve the clinical use of these compounds.

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Acknowledgements

We acknowledge the help in taking care of the animals of the staffs of the Animal Quarter from the IFR 31 and more specially JM Lerme and Y Barreira. We thank AM Bessac for HPLC analysis; A Guédin for technical assistance; JJ Maoret and E Arnaud for real-time PCR assistance; C Chanut and M André for their recommendations on cell culture in semisolid medium; B Morio (UMPE, Clermont Ferrand, France) for setting the palmitic acid oxidation technique; JP Giacobino for helpful discussion. MC Carmona, K Louche, Y Jeanson and B Lefebvre were founded by Institut de Recherche Servier.

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Authors and Affiliations

  1. UMR 5241 UPS-CNRS, IFR109, CHU Rangueil, Toulouse Cedex, France

    M C Carmona, A Galinier, A Benani, Y Jeanson, K Louche, L Pénicaud & L Casteilla

  2. U459 INSERM, Lille, France

    P Lefebvre, B Lefebvre & S Flajollet

  3. Division of Metabolic Diseases, Institut de Recherches Servier, Suresnes, France

    A Ktorza & C Dacquet

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  1. M C Carmona
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  2. P Lefebvre
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from the Consortium of the French Ministry of Research and Technology: ‘Molecules and New Therapeutic Targets’

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Correspondence to L Casteilla.

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All the authors declare no conflict of interest.

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Carmona, M., Lefebvre, P., Lefebvre, B. et al. Coadministration of Coenzyme Q prevents Rosiglitazone-induced adipogenesis in ob/ob mice. Int J Obes 33, 204–211 (2009). https://doi.org/10.1038/ijo.2008.265

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  • DOI: https://doi.org/10.1038/ijo.2008.265

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