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Limited effect of testosterone treatment for erectile dysfunction caused by high-estrogen levels in rats

International Journal of Impotence Research volume 25, pages 201–205 (2013)Cite this article

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Abstract

Some studies suggest that high-estrogen levels lead to erectile dysfunction (ED); high-estrogen levels are known to decrease testosterone levels. However, no study has examined whether testosterone replacement can improve the ED induced by high-estrogen levels. We investigated the effects of testosterone on ED caused by high-estrogen levels in rats. Rats were distributed in the following groups: (1) control (vehicle for 2 weeks), (2) the estrogen-treated group (ES; estradiol (3 μg kg−1 day−1) for 2 weeks), and (3) the estrogen- and testosterone-treated group (ES+TE; estradiol (3 μg kg−1 day−1) and testosterone (3 mg kg−1 day−1) for 2 weeks). We measured smooth muscle function via isometric tension and erectile function by measuring the intracavernosal pressure on cavernous nerve stimulation. In the ES group, the contraction of the corpus cavernosum smooth muscle increased in response to noradrenalin, and its relaxation decreased in response to the nitric oxide donor, sodium nitroprusside. Further, the erectile function was significantly decreased. In the ES+TE group, neither smooth muscle function nor erectile function was significantly improved. In conclusion, a high-estrogen milieu affected erectile function in rats, and testosterone treatment did not improve the ED caused by high-estrogen levels.

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Authors and Affiliations

  1. Department of Hospital Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan

    T Kataoka, Y Hotta, M Ohno, Y Maeda & K Kimura

  2. Department of Clinical Pharmacy, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan

    K Kimura

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  1. T Kataoka
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Correspondence to K Kimura.

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Kataoka, T., Hotta, Y., Ohno, M. et al. Limited effect of testosterone treatment for erectile dysfunction caused by high-estrogen levels in rats. Int J Impot Res 25, 201–205 (2013). https://doi.org/10.1038/ijir.2013.21

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