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Improvements in confidence, sexual relationship and satisfaction measures: results of a randomized trial of tadalafil 5 mg taken once daily

International Journal of Impotence Research volume 21, pages 240–248 (2009)Cite this article

Abstract

An efficacy study of tadalafil (5 mg once daily) for treating erectile dysfunction included sexual satisfaction and psychosocial outcome measures such as Treatment satisfaction (THX) domain of Sexual Life Quality Questionnaire, Self-Esteem And Relationship (SEAR) questionnaire, Sexual Encounter Profile questions 4 (SEP4; hardness satisfaction) and 5 (SEP5; overall satisfaction), intercourse satisfaction (IS) and overall satisfaction (OS) domains of International Index of Erectile Function (IIEF), and partner SEP question 3 (pSEP3). After a 4-week run-in phase, participants were randomized to receive either tadalafil (N=264) or placebo (N=78) for 12 weeks. Participants and partners were more satisfied (THX) with tadalafil (75 and 73, respectively) than with placebo (51 and 55, respectively, P<0.001). Statistically significant improvements in sexual relationship, confidence, self-esteem and overall relationship (SEAR), in addition to IS, OS, SEP5 and pSEP3 for tadalafil compared with placebo (P<0.001) correlated with erectile function (EF) improvement (assessed by change from baseline in IIEF-EF score). Tadalafil significantly improved treatment and sexual satisfaction, while improving multiple outcomes measured by SEAR.

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Acknowledgements

This work was sponsored by Eli Lilly and Company, including assistance with manuscript preparation provided by Laura Bean Warner, i3 Statprobe.

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Authors and Affiliations

  1. Department of Urology, Case Medical Center/University Hospitals of Cleveland, Cleveland, OH, USA

    A D Seftel

  2. CETPARP, Lille, France

    J Buvat

  3. Center for Marital and Sexual Health of South Florida, West Palm Beach, FL, USA

    S E Althof

  4. Medical Affiliated Research Center, Huntsville, AL, USA

    J G McMurray

  5. Lilly USA, LLC, Lilly Corporate Center, Indianapolis, IN, USA

    H L Zeigler, P R Burns & D G Wong

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  1. A D Seftel
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Correspondence to A D Seftel.

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Seftel, A., Buvat, J., Althof, S. et al. Improvements in confidence, sexual relationship and satisfaction measures: results of a randomized trial of tadalafil 5 mg taken once daily. Int J Impot Res 21, 240–248 (2009). https://doi.org/10.1038/ijir.2009.22

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