Abstract
High blood pressure (BP) is a major determinant of cardiovascular events in obesity. The β2- and β3-adrenoceptor polymorphisms are associated with obesity and hypertension. In the present study, we examine the relationships of β2- and β3-adrenoceptor polymorphisms with further weight gain–induced BP elevation in obese subjects. Changes in BP, body weight, total body fat-mass, waist-to-hip ratio, plasma norepinephrine (NE) and leptin levels, and β2(Arg16Gly)- and β3(Trp64Arg)-adrenoceptor polymorphisms were measured periodically over a 5-year period in 55 entry obese (body mass index [BMI]≥25.0 kg/m2) normotensive (BP<140/90 mmHg) men. BP elevation and weight gain were defined as ≥10% increases from entry levels over 5 years in mean BP or BMI. Obese subjects with weight gain, BP elevation or weight gain–induced BP elevation had higher frequencies of the Gly16 allele of Arg16Gly and Arg64 allele of Trp64Arg. Subjects carrying the Gly16 or Arg64 alleles had significantly greater total fat-mass and waist-to-hip ratio at entry and over a 5-year period compared to the subjects who did not carry these polymorphisms. Subjects carrying the Gly16 allele had similar levels of plasma NE, higher levels of plasma leptin and a lower slope of the regression lines between plasma leptin and NE levels. Those carrying the Arg64 allele had higher plasma NE levels at entry and over a 5-year period compared to the subjects without the Arg64 allele, but plasma leptin levels and slopes were similar. The findings demonstrate that the Arg64 allele of the β3-adrenoceptor polymorphisms relates to weight gain–induced BP elevation accompanying high plasma NE (heightened sympathetic activity) in obese men. The Gly16 allele of the β2-adrenoceptor polymorphisms links to weight gain–induced BP elevation associated with leptin resistance. β2- and β3-adrenoceptor polymorphisms could predict the future BP elevation and further weight gain–induced BP elevation in originally obese subjects.
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Kawaguchi, H., Masuo, K., Katsuya, T. et al. β2- and β3-Adrenoceptor Polymorphisms Relate to Subsequent Weight Gain and Blood Pressure Elevation in Obese Normotensive Individuals. Hypertens Res 29, 951–959 (2006). https://doi.org/10.1291/hypres.29.951
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DOI: https://doi.org/10.1291/hypres.29.951
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