Abstract
Gametic disequilibrium between RFLP sites have been used to infer recombinational hotspots. However, some measures of gametic disequilibrium, such as the correlation coefficient, are quite dependent upon allelic frequencies. The normalized disequilibrium measure of Lewontin, on the other hand, is independent of allelic frequencies. Data from the β-globin gene cluster are used as an illustration of such potential misinterpretations and the use of these measures.
Similar content being viewed by others
Article PDF
References
Chakravarti, A, Buetow, K H, and Antonarakis, S E et al. 1984. Nonuniform recombination within the human β-globin gene cluster. Am J Hum Genet, 36, 1239–1258.
Chakravarti, A, Buetow, K H, and Antonarakis, S E et al. 1986. Nonuniform recombination within the human β-globin gene cluster: A reply to B. S. Weir and W. G. Hill. Am J Hum Genet, 38, 779–781.
Clegg, M T, Kidwell, J F, Kidwell, M G, and Daniel, N J. 1976. Dynamics of correlated genetic systems. I. Selection in the region of the Glued locus of Dropsophila melanogaster. Genetics, 83, 793–810.
Donald, J A, and Ball, S P. 1984. Approximate linkage equilibrium between two polymorphic sites within the gene for human complement component 3. Ann Hum Genet, 48, 269–273.
Hedrick, P W. Gametic disequilibrium measures: Proceed with caution. Genetics, 117, 331–341.
Hill, W G, and Robertson, A. 1968. Linkage disequilibrium of finite populations. Theoret Appl Genet, 38, 226–231.
Hudson, R R, and Kaplan, N L. 1985. Statistical properties of the number of recombination events in the history of a sample of DNA sequences. Genetics, 222, 147–164.
Kendall, M G, and Stuart, A. 1961. The Advanced Theory of Statistics, Vol.II.Charles Griffin and Co., London.
Lewontin, R C. 1984. The interaction of selection and linkage. I. General considerations; heterotic models. Genetics, 49, 49–67.
Litt, M, and Jorde, L B. 1986. Linkage disequilibria between pairs of loci within a highly polymorphic region of chromosome 2Q. Am J Hum Genet, 39, 166–178.
Nei, M. 1987. Molecular Evolutionary Genetics. Columbia Univ. Press, New York.
Nei, M, and Li, W-H. 1980. Non-random association between electromorphs and inversion chromosomes in finite populations. Genet Res, 35, 65–83.
Steinmetz, M, Uematsu, Y, and Lindahl, K F. 1983. Hot spots of homologous recombination in mammalian genomes. Trends Genet, 3, 7–10.
Thomson, G, and Baur, M P. 1984. Third order linkage disequilibrium. Tissue Antigens, 24, 250–255.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hedrick, P. Inference of recombinational hotspots using gametic disequilibrium values. Heredity 60, 435–438 (1988). https://doi.org/10.1038/hdy.1988.61
Received:
Issue Date:
DOI: https://doi.org/10.1038/hdy.1988.61
This article is cited by
-
Where the crossovers are: recombination distributions in mammals
Nature Reviews Genetics (2004)
-
Meiotic recombination hot spots and cold spots
Nature Reviews Genetics (2001)
-
Mutation and linkage disequilibrium in human mtDNA
European Journal of Human Genetics (2001)
-
Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex
Nature Genetics (2001)