Summary
There is increasing support for the notion that changes in regulatory loci have played a major role in eukaryotic evolution. Assuming a model of genetic regulation based upon presently accepted views of the organisation of the eukaryotic genome and basic models of evolutionary genetics, one can provide a context for speculation about the advantages and disadvantages of adaptation via regulatory genes. As additional information is obtained on particular regulatory systems, the evolutionary genetic model can be modified and expanded.
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Ashburner, M. 1970. Function and structure of polytene chromosomes during insect development. Adv Insect Physiol, 7, 1–95.
Avise, J C. 1974. Systematic value of electrophoretic data. Syst Zool, 23, 465–481.
Avise, J C. 1976. Genetic differentiation during speciation. In Molecular Evolution, ed. F.J. Ayala. Sinauer Assoc., Sunderland, Mass., 106–122.
Ayala, F J. 1975. Genetic differentiation during the speciation. Evol Biol, 8, 1–78.
Baker, W K. 1978. A genetic framework for Drosophila development. Ann Rev Genet, 12, 451–470.
Barnes, B W, and Birley, A J. 1978. Genetical variation for enzyme activity in a population of Drosophila melanogaster. IV. Analysis of alcohol dehydrogenase activity in chromosome substitution lines. Heredity, 40, 51–57.
Britten, R J, and Davidson, E H. 1969. Gene regulation for higher cells: A theory. Science, 165, 349–357.
Dickinson, W J. 1978. Genetic control of enzyme expression in Drosophila: a locus influencing tissue specificity of aldehyde oxidase. J Exp Zool, 260, 333–342.
Dickson, R C, Abelson, J, Barnes, W M, and Reznikoff, W S. 1975. Genetic regulation: The lac control region. Science, 187, 27–35.
Fisher, R A. 1958. The Genetical Theory of Natural Selection. Second edition. Dover, New York.
Garcia-Bellido, A. 1975. Genetic control of wing disc development. In Cell Patterning, eds. R. Porter and J. Rivers. Associated Scientific Publishers, New York, 161–182.
Garcia-Bellido, A. 1977. Homoeotic and atavic mutations in insects. Amer Zool, 17, 613–329.
Gillespie, J A, and Langley, C H. 1974. A general model to account for enzyme variation in natural populations. Genetics, 76, 837–948.
Goldschmidt, R. 1930. The Material Basis of Evolution. Yale Univ. Press, New Haven, Conn.
Hedrick, P W, Jain, S, and Holden, L. 1978. Multilocus systems in evolution. Evol Biol, 11, 101–184.
Hood, L E, Wilson, J H, and Wood, W B. 1975. Molecular Biology of Eucaryotic Cells. W. A. Benjamin, Inc., Menlo Park, California.
Kerr, W E, Akahira, Y, and Camargo, C A. 1975. Sex determination in bees. IV. Genetic control of juvenile hormone production in Melipona quadrifasciata (Apidae). Genetics, 81, 749–756.
King, M C, and Wilson, A C. 1975. Evolution at two levels: Molecular similarities and biological differences between humans and chimpanzees. Science, 188, 107–116.
Laurie-Ahlberg, C C, Maroni, G P, Bewley, G C, Luchesi, J C, and Weir, B S. 1980. Quantitative genetic variation of enzyme activities in natural populations of Drosophila melanogaster. Proc Natl Acad Sci. 77, 1073–1077.
Lewin, B. 1974. Gene expression—1 Bacterial Genomes. Wiley, New York.
Lewis, E B. 1978. A gene complex controlling segmentation in Drosophila. Nature, 276, 565–560.
Lin, E C C, Hacking, A J, and Aquilar, J. 1976. Experimental models of acquisitive evolution. Bioscience, 26, 458–555.
Maroni, G. 1978. Genetic control of alcohol dehydrogenase levels in Drosophila. Biochem Genetics, 16, 509–523.
MacIntyre, R, and O'Brien, S. 1976. Interacting gene-enzyme in Drosophila. Ann Rev Genet, 10, 281–318.
McDonald, J F, and Ayala, F J. 1978. Genetic and biochemical basis of enzyme activity variation in natural populations. I. Alcohol dehydrogenase in Drosophila melanogaster. Genetics, 89, 371–388.
McDonald, J F, Chambers, G K, David, J, and Ayala, J F. 1977. Adaptive response due to changes in gene regulation: a study with Drosophila. Proc Natl Acad Sci, 74, 4562–4566.
McKusick, V A, and Ruddle, F H. 1977. The status of the gene map of the human chromosomes. Science, 196, 390–405.
Nair, P S, Carson, H L, and Sene, F M. 1977. Isozyme polymorphism due to regulatory influence. Amer Natur, 111, 789–791.
Radinsky, L. 1978. Do albumin clocks run on time? Science, 200, 1182–1183.
Selander, R K, and Johnson, W E. 1973. Genetic variation among vertebrate species. Ann Rev Ecol Syst, 4, 75–91.
Sene, F M, and Carson, H L. 1977. Genetic variation in Hawaiian Drosophila. IV. Allozymic similarity between D. silvestris and D. heteroneura from the island of Hawaii. Genetics, 86, 187–198.
Simpson, G G. 1944. Tempo and Mode in Evolution. Columbia University Press, New York.
Simpson, G G. 1953. The Major Features of Evolution. Columbia University Press, New York.
Soll, D. 1979. Timers in developing systems. Science, 203, 841–849.
Stebbins, G L. 1969. The Basis of Progressive Evolution. Univ. North Carolina Press, Chapel Hill.
Stein, G S, and Kleinsmith, L J. 1975. Chromosome Proteins and Their Role in the Regulation of Gene Expression. Academic Press, New York.
Stein, G S, and Stein, J L. 1976. Chromosomal proteins: their role in the regulation of gene expression. Bioscience, 26, 488–498.
Thompson, J N, Ashburner, M, and Woodruff, R C. 1977. Presumptive control mutation for alcohol dehydrogenase in Drosophila melanogaster. Nature, 270, 363.
Turner, J R G, Johnson, M S, and Eanes, W F. 1979. Contrasted modes of evolution in the same genome: Allozymes and adaptive change in Heliconius. Proc Natl Acad Sci, 76, 1924–1928.
Valentine, J, and Campbell, C. 1975. Genetic regulation and the fossil record. Amer Sci, 63, 673–680.
Wallace, B. 1963. Genetic diversity, genetic uniformity and heterosis. Canad J Genet Cytol, 5, 239–253.
Ward, R. 1975. Alcohol dehydrogenase activity in Drosophila melanogaster: a quantitative character. Genet Res, 26, 81–93.
White, M J D. 1978. Modes of Speciation. W. H. Freeman, San Francisco.
Wilson, A C. 1975. Evolutionary importance of gene regulation. Stadler Symp, 7, 117–133.
Wright, S. 1969. Evolution and the Genetics of Population II The Theory of Gene Frequencies. Univ. Chicago Press, Chicago.
Zuckerkandl, E. 1963. Perspectives in molecular anthropology. In Classification and Human Evolution, ed. S. L. Washburn. Aldine Publ. Co., Chicago, 243–272.
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Hedrick, P., McDonald, J. Regulatory gene adaptation: An evolutionary model. Heredity 45, 83–97 (1980). https://doi.org/10.1038/hdy.1980.52
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DOI: https://doi.org/10.1038/hdy.1980.52
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